Synthesis and Evaluation of Trehalose-Based Mertansine Warheads for Bacillus Calmette-Guérin Delivery of Anticancer Agents
文献类型：期刊论文
| 作者 | Grimmeisen, Michael4; Wang, Xuan3,4; Weldle, Melissa4; Sartory, Kerstin4; Benkhelifa, Sara4; Zhang, Yu4; Dao, Trinh2,4; Meyer, Jonas4; Gorka, Oliver1; Gross, Olaf1,2 |
| 刊名 | CHEMBIOCHEM
 |
| 出版日期 | 2025-07-09 |
| 页码 | 10 |
| 关键词 | antigen 85 complex anti cancer agents bladder cancer delivery mertansine mycobacteria trehalose |
| ISSN号 | 1439-4227 |
| DOI | 10.1002/cbic.202500390 |
| 通讯作者 | Jessen-Trefzer, Claudia(claudia.jessen-trefzer@pharmazie.uni-freiburg.de) |
| 英文摘要 | Nonmuscle invasive bladder cancer (NMIBC) accounts for 75% of bladder cancer cases, with Bacillus Calmette-Gu & eacute;rin (BCG) immunotherapy as the gold standard for high-risk patients. BCG elicits a robust immune response but is limited by adverse effects and resistance. To enhance its efficacy, a trehalose-based conjugation strategy is developed, tethering a cytostatic agent to BCG via a cleavable disulfide linker. This system enables selective drug integration into the BCG envelope and controlled release in tumor cells, aiming to improve therapeutic precision while minimizing toxicity. This approach combines immunotherapy with targeted chemotherapy, offering a promising strategy for NMIBC treatment. |
| WOS关键词 | MYCOBACTERIUM-BOVIS BCG ; CALMETTE-GUERIN ; IN-VITRO ; INTRAVESICAL IMMUNOTHERAPY ; BLADDER ; TUBERCULOSIS ; EFFICACY ; THERAPY ; VIVO ; CYTOTOXICITY |
| 资助项目 | Deutsche Forschungsgemeinschaft ; Medical Faculty, University of Freiburg[2023/A2-Fol] ; Medical Faculty, University of Freiburg[2021/B3] ; Deutsches Konsortium fr Translationale Krebsforschung ; Mertelsmann Foundation ; DFG[450392965] ; High-level Innovative Research Institute[2021B0909050003] ; Centre for Biological Signalling Studies (BIOSS) ; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) ; Open Access Publication Fund of the University of Freiburg |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001524640400001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321051]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Jessen-Trefzer, Claudia |
| 作者单位 | 1.Univ Freiburg, Univ Med Ctr, Inst Neuropathol, Fac Med, Breisacher Str 113, D-79106 Freiburg, Germany 2.Univ Freiburg, CIBSS Ctr Integrat Biol Signalling Studies, Schanzlestr 18, D-79104 Freiburg, Germany 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 4.Univ Freiburg, Inst Organ Chem, Albertstr 21, D-79104 Freiburg, Germany |
| 推荐引用方式 GB/T 7714 | Grimmeisen, Michael,Wang, Xuan,Weldle, Melissa,et al. Synthesis and Evaluation of Trehalose-Based Mertansine Warheads for Bacillus Calmette-Guérin Delivery of Anticancer Agents[J]. CHEMBIOCHEM,2025:10. |
| APA | Grimmeisen, Michael.,Wang, Xuan.,Weldle, Melissa.,Sartory, Kerstin.,Benkhelifa, Sara.,...&Jessen-Trefzer, Claudia.(2025).Synthesis and Evaluation of Trehalose-Based Mertansine Warheads for Bacillus Calmette-Guérin Delivery of Anticancer Agents.CHEMBIOCHEM,10. |
| MLA | Grimmeisen, Michael,et al."Synthesis and Evaluation of Trehalose-Based Mertansine Warheads for Bacillus Calmette-Guérin Delivery of Anticancer Agents".CHEMBIOCHEM (2025):10. |
入库方式： OAI收割
来源：上海药物研究所
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