Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption
文献类型：期刊论文
| 作者 | Huang, Chenxi5,6; Xin, Xiaohong3,4; Hao, Xiaoxu6; Zhou, Shilin6; Xie, Zongneng6; He, Lijuan6; Li, Xiaoliang6; Zhang, Yu3,4; Sun, Hongyu5,6; Zhang, Jiwen1,2 |
| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2025-07-23 |
| 卷号 | 11期号:30页码:15 |
| DOI | 10.1126/sciadv.adw8330 |
| 通讯作者 | Zhang, Jiwen(xzyin@lglab.ac.cn) ; Zhang, Xiaochuan(zxc@simm.ac.cn) ; Yin, Xianzhen(jwzhang@simm.ac.cn) |
| 英文摘要 | Vasculature-induced tumor tissue heterogeneity impedes predicable drug distribution and presents notable challenges for optimizing nanoparticle (NP)-based drug delivery. However, mesoscopic-scale tumor heterogeneity across entire brain remains poorly characterized. To address this, we integrated micro-optical sectioning tomography (MOST) with high-precision three-dimensional (3D) reconstruction analysis to map pathological features of orthotopic glioma at submicron resolution across whole mice brain. Our findings uncovered significant heterogeneity in glioma invasiveness, vasculature, and compensatory angiogenesis while precisely delineating NP distribution throughout the tumor. Notably, early-stage glioma co-opted and migrated 680-micrometer upstream along the main cerebral artery within 4 days after glioma implantation. Blood-brain barrier permeability gradually increased during glioma progression, enabling NP penetrated via large-diameter vessels instead being restricted to capillaries. This work establishes a multiscale, high-resolution, 3D atlas of glioma heterogeneity and NP distribution, and bridges mesoscopic structural complexity to functional drug delivery barriers, advancing strategies to enhance oncotherapy precision in heterogeneous brain tumors. |
| WOS关键词 | IN-VIVO ; STRATEGIES ; ATLAS |
| 资助项目 | Research Foundation of Lingang Laboratory[LG-QS-202206-04] ; National Natural Science Foundation of China[82273863] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001534465000001 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321084]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jiwen; Zhang, Xiaochuan; Yin, Xianzhen |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Ctr MOST & Image Fus Anal, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 6.Lingang Lab, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Chenxi,Xin, Xiaohong,Hao, Xiaoxu,et al. Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption[J]. SCIENCE ADVANCES,2025,11(30):15. |
| APA | Huang, Chenxi.,Xin, Xiaohong.,Hao, Xiaoxu.,Zhou, Shilin.,Xie, Zongneng.,...&Yin, Xianzhen.(2025).Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption.SCIENCE ADVANCES,11(30),15. |
| MLA | Huang, Chenxi,et al."Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption".SCIENCE ADVANCES 11.30(2025):15. |
入库方式： OAI收割
来源：上海药物研究所
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