Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease via a Galactose-Modified Supramolecular Near-Infrared Fluorescent Glycoprobe
文献类型：期刊论文
| 作者 | Wang, Han-Min9,10; Dong, Lei8; Hao, Qiu-Lian10; Sun, Lu-Lu10; Li, Xin-Rong3,9,10; Yuan, Yu-Wei10; Tang, Ming-Ye1; Gong, Jin8; Zang, Yi5; Li, Jia3,9,10 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2025-07-24 |
| 页码 | 13 |
| 关键词 | fluorescent glycoprobe lipid droplets liver targeting metabolic dysfunction-associated steatotic liver disease (MASLD) near-infrared |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.202425887 |
| 通讯作者 | Gong, Jin(gongjin@sdsmu.edu.cn) ; Zang, Yi(yzang@lglab.ac.cn) ; Li, Jia(jli@simm.ac.cn) ; James, Tony D.(t.d.james@bath.ac.uk) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; Han, Hai-Hao(hanhaihao@simm.ac.cn) |
| 英文摘要 | Metabolic dysfunction-associated steatotic liver disease (MASLD) has become an important liver disease worldwide due to the rising rate of type 2 diabetes, obesity, and other metabolic disorders. The early detection of MASLD is vital to slow progression to cirrhosis and hepatocellular carcinoma; yet, existing research tools for studying hepatic steatosis are limited in terms of their effectiveness and invasiveness. Herein, a near-infrared (NIR) fluorescent probe, TCF-FBN, for the selective imaging of lipid droplets (LDs) in MASLD is reported. TCF-FBN exhibits bright NIR fluorescence and a large Stokes shift in nonpolar solvents, and minimal fluorescence in polar solvents, making it suitable for biological imaging. The probe is bound to bovine serum albumin (BSA) through supramolecular forces to enhance its biocompatibility, and the resulting TCF-FBN@BSA ensemble is used for fluorescence imaging of LDs generated in hepatocytes. Notably, the modification of TCF-FBN@BSA with galactosyl ligands producing TCF-FBN@Gal-BSA enables the targeted imaging of the liver of mice with MASLD via asialoglycoprotein receptor (ASGPR)-mediated biorecognition. |
| 资助项目 | Key R&D Program of Shandong Province, China ; National Natural Science Foundation of China[22377135] ; National Natural Science Foundation of China[22107029] ; National Natural Science Foundation of China[22207086] ; National Natural Science Foundation of China[92253306] ; Natural Science Foundation of Shandong Province, China[ZR2022QH060] ; Natural Science Foundation of Shandong Province, China[ZR2024QC378] ; Taishan Scholars Program[tsqn202312305] ; Taishan Scholars Program[tstp0648] ; Young Elite Scientists Sponsorship Program by Chinese Chemical Society ; Fundamental Research Projects of Science & Technology Innovation and development Plan in Yantai City[2023JCYJ059] ; Shandong Laboratory Program[SYS202205] ; Science and Technology Commission of Shanghai Municipality[24DX1400200] ; International Cooperation Program of Shanghai Science and Technology[23490711600] ; Shanghai Xuhui District Hospital Local Cooperation Project[23XHYD-20] ; Dalian University of Technology[KF 2402] ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; State Key Laboratory of Bioreactor Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University ; Ministry of Education Key Laboratory on signaling Regulation and Targeting Therapy of Liver Cancer (Naval Medical University)[2023-MEKLLC-MS/ZD-00] ; University of Bath ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01] ; [2024CXPT028] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001534997100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321093]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Gong, Jin; Zang, Yi; Li, Jia; James, Tony D.; He, Xiao-Peng; Han, Hai-Hao |
| 作者单位 | 1.Nantong Univ, Xinglin Coll, Wuxi Huishan Dist Peoples Hosp, Affiliated Huishan Hosp, Wuxi 214187, Jiangsu, Peoples R China 2.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Univ Bath, Dept Chem, Bath BA2 7AY, Somerset, England 5.Lingang Lab, Shanghai 201203, Peoples R China 6.Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China 7.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat & Joint Int Re, 130 Meilong Rd, Shanghai 200237, Peoples R China 8.Shandong Second Med Univ, Sch Pharm, Weifang 261053, Peoples R China 9.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Natl Ctr Drug Screening,Stake Key Lab Chem Biol, Shanghai 201203, Peoples R China 10.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Han-Min,Dong, Lei,Hao, Qiu-Lian,et al. Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease via a Galactose-Modified Supramolecular Near-Infrared Fluorescent Glycoprobe[J]. ADVANCED FUNCTIONAL MATERIALS,2025:13. |
| APA | Wang, Han-Min.,Dong, Lei.,Hao, Qiu-Lian.,Sun, Lu-Lu.,Li, Xin-Rong.,...&Han, Hai-Hao.(2025).Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease via a Galactose-Modified Supramolecular Near-Infrared Fluorescent Glycoprobe.ADVANCED FUNCTIONAL MATERIALS,13. |
| MLA | Wang, Han-Min,et al."Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease via a Galactose-Modified Supramolecular Near-Infrared Fluorescent Glycoprobe".ADVANCED FUNCTIONAL MATERIALS (2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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