Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities
文献类型：期刊论文
| 作者 | Feng, Mingyang2; He, Yong1; Wang, Hui2 |
| 刊名 | FRONTIERS IN PHARMACOLOGY
 |
| 出版日期 | 2025-07-11 |
| 卷号 | 16页码:13 |
| 关键词 | annexins ANXA2 liver disease MAFLD HCC |
| DOI | 10.3389/fphar.2025.1569927 |
| 通讯作者 | Wang, Hui(wanghuirj@163.com) |
| 英文摘要 | The Annexin (ANXA) protein family, which is ubiquitously expressed across various tissues, encodes versatile calcium (Ca2+)- and phospholipid-binding proteins that play crucial roles in modulating inflammation and cell signaling pathways. This family significantly influences several essential cellular processes, including cell adhesion, proliferation, migration, differentiation, and apoptosis. ANXAs are integral to physiological regulation and the pathological states associated with liver diseases. Dysregulated expression of ANXAs has been linked to a spectrum of liver conditions, including metabolic dysfunction, hepatocyte damage, fibrosis, and tumor formation. In this review, we outline recent advancements in understanding the roles of ANXAs in liver diseases. Further investigation into the roles of ANXAs in the liver could enhance our understanding of the mechanisms underlying liver diseases and may identify biomarkers and therapeutic targets for liver diseases in the future. |
| WOS关键词 | HEPATITIS-B-VIRUS ; HEPATOCELLULAR-CARCINOMA ; GENE-EXPRESSION ; CELL-LINE ; DOWN-REGULATION ; A2 ; HBV ; TARGET ; A1 ; A3 |
| 资助项目 | Shanghai Municipal Health Commission10.13039/100017950 |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001534818900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321108]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Hui |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Infect Dis, Sch Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Mingyang,He, Yong,Wang, Hui. Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities[J]. FRONTIERS IN PHARMACOLOGY,2025,16:13. |
| APA | Feng, Mingyang,He, Yong,&Wang, Hui.(2025).Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities.FRONTIERS IN PHARMACOLOGY,16,13. |
| MLA | Feng, Mingyang,et al."Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities".FRONTIERS IN PHARMACOLOGY 16(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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