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Vimentin intermediate filaments facilitate transportation of hepatitis C virus components

文献类型：期刊论文

作者Xing, Yifan4,5,6; Cui, Shuzhi5; Huang, Xinyi5; Zhao, Weisong3; Li, Haoyu3; Zhao, Jing5; Chang, Wakam2; Zhao, Shuangshuang1,4,5; Zhong, Jin1,4,5; Chen, Yuxin6
刊名EUROPEAN JOURNAL OF CELL BIOLOGY
出版日期2025-09-01
卷号104期号:3页码:8
关键词Intermediate filaments Cytoskeletal vimentin Viral cell-cell transmission Hepatitis C virus Host-pathogen interaction
ISSN号0171-9335
DOI10.1016/j.ejcb.2025.151505
通讯作者Xing, Yifan(yfxing@siii.cas.cn) ; Zhao, Shuangshuang(sszhao2@siii.cas.cn) ; Zhong, Jin(jzhong@siii.cas.cn) ; Chen, Yuxin(yuxin.chen@nju.edu.cn) ; Jiu, Yaming(ymjiu@siii.cas.cn)
英文摘要Vimentin, an intermediate filament protein, primarily contributes to intracellular organization, cell migration, and signal transduction. In recent years, the role of intermediate filaments in viral infection has garnered increasing attention. During viral infection, vimentin can regulate viral propagation by forming a vimentin cage to enclose viral replication factories, and facilitating the intracellular transport of viral components. However, whether vimentin can facilitate cell-to-cell transfer of viral components remains unknown. In this study, using hepatitis C virus (HCV) as a viral model, we demonstrated that HCV infection does not induce large-scale vimentin rearrangement or the formation of a vimentin cage. Interestingly, we observed that HCV components move directionally along a vimentin-containing cellular bridge from highly infected donor cells towards neighboring cells, potentially facilitating viral dissemination. Together, our findings unveil a previously unrecognized function of vimentin in the viral life cycle, expanding our understanding of the complex interplay between host cellular factors and viral strategies.
WOS关键词IN-VITRO ; CELL ; CYTOSKELETON ; MECHANICS ; SPREAD ; ACTIN
资助项目National Natural Science Foundation of China[32222022] ; National Natural Science Foundation of China[92354301] ; National Natural Science Foundation of China[92054104] ; Key Research and Development Program, Ministry of Science and Technology of China[2024YFC2310003] ; Key Research and Development Program, Ministry of Science and Technology of China[2022YFC2303502] ; R & D Program of Guangzhou National Laboratory[GZNL2023A03004] ; National Natural Science Foundation of Shanghai[23ZR1470900] ; The 100 talents program from the Chinese Academy of Sciences ; Fundo para o Desenvolvimento das Ciencias e da Tecnologia, Macau[0099/2022/AFJ]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:001537497300001
出版者ELSEVIER GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/321123]  
专题中国科学院上海药物研究所
通讯作者Xing, Yifan; Zhao, Shuangshuang; Zhong, Jin; Chen, Yuxin; Jiu, Yaming
作者单位1.Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China
2.Univ Macau, Fac Hlth Sci, Dept Biomed Sci, Taipa 519000, Macao, Peoples R China
3.Harbin Inst Technol, Frontier Sci Ctr Interact Space Environm & Matter, State Key Lab Matter Behav Space Environm, Sch Instrumentat Sci & Engn,Innovat Photon & Imagi, Harbin 150080, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Key Lab Mol Virol & Immunol, Shanghai Inst Immun & Infect, Shanghai 200031, Peoples R China
6.Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Lab Med,Med Sch, Nanjing 210008, Peoples R China
推荐引用方式
GB/T 7714		 Xing, Yifan,Cui, Shuzhi,Huang, Xinyi,et al. Vimentin intermediate filaments facilitate transportation of hepatitis C virus components[J]. EUROPEAN JOURNAL OF CELL BIOLOGY,2025,104(3):8.
APA Xing, Yifan.,Cui, Shuzhi.,Huang, Xinyi.,Zhao, Weisong.,Li, Haoyu.,...&Jiu, Yaming.(2025).Vimentin intermediate filaments facilitate transportation of hepatitis C virus components.EUROPEAN JOURNAL OF CELL BIOLOGY,104(3),8.
MLA Xing, Yifan,et al."Vimentin intermediate filaments facilitate transportation of hepatitis C virus components".EUROPEAN JOURNAL OF CELL BIOLOGY 104.3(2025):8.

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来源：上海药物研究所

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