Chemometrics-driven LC-MS analysis reveals key metabolites and chemical diversity in Abrus cantoniensis Hance stems and leaves
文献类型：期刊论文
| 作者 | Xu, Yan-bo2,3; Liu, Xiao-kang2; Wang, Jia-wei2,3; Xia, Ti-yu2,3; Jiang, Hui-ling2,3; Feng, Lin2; An, Ya-ling2; Li, Zhen-wei2; Zhang, Dai-di2; Guo, De-an1,2,3 |
| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2025-09-27 |
| 卷号 | 1759页码:15 |
| 关键词 | Abrus cantoniensis Hance UPLC-Q-TOF-MS/MS Chemical constituents Differential metabolites Quality control |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/j.chroma.2025.466233 |
| 通讯作者 | Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Abrus cantoniensis Hance (A. cantoniensis) is a common medicinal and edible plant. Its stems and leaves are widely used in food, pharmaceutical, and daily chemical products. However, the leaves of A. cantoniensis often detach during processing, leading to substantial quality variations. This study aimed to develop an identification method by analyzing the differences in characteristic components between stems and leaves, thereby improving the quality control standards of A. cantoniensis. A total of 130 chemical components of A. cantoniensis were identified using UPLC-Q-TOF-MS/MS, comprising 44 flavonoids, 25 triterpenoids, 15 organic acids, and 46 compounds from other categories. PCA revealed distinct clustering of stems and leaves, indicating considerable compositional divergence. OPLS-DA further identified 34 differential metabolites, with stems predominantly enriched in organic acids (e.g., chlorogenic acid and neochlorogenic acid), whereas leaves exhibited higher levels of C-glycosyl flavonoids, notably vicenin II and schaftoside. Quantitative analysis revealed that the contents of vicenin II and schaftoside in leaves were similar to 100- and similar to 40-fold higher, respectively, than those in stems. The contents of the three components were as follows: chlorogenic acid (0.027, 0.052, and 0.002 mg/g), vicenin II (0.295, 0.008, and 0.081 mg/g), and schaftoside (0.362, 0.023, and 0.928 mg/g). These findings indicate the substantial chemical heterogeneity between the stems and leaves of A. cantoniensis, with vicenin II and schaftoside serving as key biomarkers for leaves. The results provide a scientific basis for refining the quality control protocols of A. cantoniensis-derived herbal materials by enabling tissue-specific authentication and standardization. |
| 资助项目 | Sanming Project of Medicine in Shenzhen[SZZYSM202106004] ; National Administration of Traditional Chinese Medicine |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001544561100001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321222]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Guangdong Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Guangzhou 510006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yan-bo,Liu, Xiao-kang,Wang, Jia-wei,et al. Chemometrics-driven LC-MS analysis reveals key metabolites and chemical diversity in Abrus cantoniensis Hance stems and leaves[J]. JOURNAL OF CHROMATOGRAPHY A,2025,1759:15. |
| APA | Xu, Yan-bo.,Liu, Xiao-kang.,Wang, Jia-wei.,Xia, Ti-yu.,Jiang, Hui-ling.,...&Guo, De-an.(2025).Chemometrics-driven LC-MS analysis reveals key metabolites and chemical diversity in Abrus cantoniensis Hance stems and leaves.JOURNAL OF CHROMATOGRAPHY A,1759,15. |
| MLA | Xu, Yan-bo,et al."Chemometrics-driven LC-MS analysis reveals key metabolites and chemical diversity in Abrus cantoniensis Hance stems and leaves".JOURNAL OF CHROMATOGRAPHY A 1759(2025):15. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。