Drug Repurposing with Topical Paclitaxel Delivery for Psoriasis Treatment Enabled by Plant-Inspired Molecular Assembly
文献类型：期刊论文
| 作者 | Liu, Han4,5,6; Xia, Wei3; Meng, Yujue2,4; Xu, Quangang4; Xia, Zihan3; Muhitdinov, Bahtiyor1; Liu, Ergang4; Shen, Huan4; Huang, Yongzhuo3,4,5,6 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2025-08-27 |
| 卷号 | 17期号:34页码:47938-47950 |
| 关键词 | self-assembly topical administration drugrepurposing paclitaxel psoriasis |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.5c08843 |
| 通讯作者 | Liu, Ergang(liuergang@zidd.ac.cn) ; Shen, Huan(shenhuan@zidd.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | Psoriasis is a chronic inflammatory skin disease, notably characterized by the hyperproliferation of epidermal cells and infiltration of inflammatory cells. Paclitaxel (PTX), beyond its canonical roles in microtubule inhibition and proliferation suppression, has recently garnered increasing attention for its promising therapeutic potential in inflammatory diseases. However, PTX is constrained by its low solubility and poor permeability in topical applications. Based on the applications of Hansen Solubility Parameters in predicting coassembled systems, we herein identified a series of herb-derived small molecules with anti-inflammatory and antioxidant properties that enhance the solubility of PTX. Among them, glycyrrhizic acid not only enhanced the solubility of PTX by nearly 400-fold but also coassembled with PTX to form nanoparticles (PGNs). PGNs featured a high PTX payload (over 30%) and notable skin retention free of excipients and surfactants. PGNs were loaded into a gel, and the resultant PGN@Gel exhibited superior therapeutic efficacy against psoriasis while concomitantly mitigating cutaneous irritation. This coassembly system provides a simple yet efficient approach for solubilizing poorly soluble drugs, thereby broadening the application of PTX-based topical delivery formulations in psoriasis treatment. |
| WOS关键词 | GLYCYRRHIZIC ACID ; MACROPHAGES ; DYNAMICS ; SYSTEM |
| 资助项目 | National Key Research and Development Program of China[2025YFE0107400] ; National Key Research and Development Program of China[2024YFA1210204] ; National Key Research and Development Program of China[2022YFE0203600] ; Department of Science and Technology of Guangdong Province[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011] ; NSFC (China)[82341232] ; NSFC (China)[82404549] ; International Partnership Program of the Chinese Academy of Sciences, CAS President's International Fellowship Initiative[083GJHZ2023012FN] ; International Partnership Program of the Chinese Academy of Sciences, CAS President's International Fellowship Initiative[083GJHZ2023021GC] ; International Partnership Program of the Chinese Academy of Sciences, CAS President's International Fellowship Initiative[2024VBB0004] ; The second batch of social welfare and basic research projects of Zhongshan city[2023B2033] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001551996500001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321264]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Ergang; Shen, Huan; Huang, Yongzhuo |
| 作者单位 | 1.Uzbek Acad Sci, Inst Bioorgan Chem, Tashkent 100125, Uzbekistan 2.China Pharmaceut Univ, Sch Pharm, Nanjing 210023, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Han,Xia, Wei,Meng, Yujue,et al. Drug Repurposing with Topical Paclitaxel Delivery for Psoriasis Treatment Enabled by Plant-Inspired Molecular Assembly[J]. ACS APPLIED MATERIALS & INTERFACES,2025,17(34):47938-47950. |
| APA | Liu, Han.,Xia, Wei.,Meng, Yujue.,Xu, Quangang.,Xia, Zihan.,...&Huang, Yongzhuo.(2025).Drug Repurposing with Topical Paclitaxel Delivery for Psoriasis Treatment Enabled by Plant-Inspired Molecular Assembly.ACS APPLIED MATERIALS & INTERFACES,17(34),47938-47950. |
| MLA | Liu, Han,et al."Drug Repurposing with Topical Paclitaxel Delivery for Psoriasis Treatment Enabled by Plant-Inspired Molecular Assembly".ACS APPLIED MATERIALS & INTERFACES 17.34(2025):47938-47950. |
入库方式： OAI收割
来源：上海药物研究所
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