Co-delivery of TRAIL DNA and salinomycin for cancer therapy via enhanced apoptosis and cancer stemness inhibition
文献类型：期刊论文
| 作者 | Zhong, Huihai5,6; Fang, Yuefei3,5; Zhao, Pengfei2; Wu, Aihua1; Nie, Guohui6; Huang, Yongzhuo4,5; Zhang, Bin6 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
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| 出版日期 | 2025-09-10 |
| 卷号 | 13期号:35页码:10926-10937 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/d5tb01203a |
| 通讯作者 | Wu, Aihua(wuaihua2016@sina.com) ; Nie, Guohui(nieguohui@email.szu.edu.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) ; Zhang, Bin(binzhang@email.szu.edu.cn) |
| 英文摘要 | Cancer treatment faces challenges including drug resistance to intrinsic apoptosis pathways and the persistence of cancer stem cells (CSCs). The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces extrinsic apoptosis in tumor cells by binding to death receptors while sparing normal cells. TRAIL-based gene therapy has emerged as a promising solution to address the short half-life limitation of recombinant TRAIL proteins. To further enhance the therapeutic efficacy, combination strategies with TRAIL sensitizer salinomycin (Sali) appear to be particularly effective. Sali not only upregulates death receptor expression and reactive oxygen species (ROS) levels but also modulates CSC-related gene expression, contributing to its multifaceted antitumor activity. In this study, a micelle system was developed for co-delivery of TRAIL plasmids (pTRAIL) and Sali to tumor sites. gamma-Polyglutamic acid (gamma-PGA)-coating improved the in vivo stability profile of the co-delivery nanocomposites. The resulting co-delivery system (gamma-PGA/Sali@P-S/pTRAIL) effectively induced apoptosis and suppressed CSC-associated gene expression in cervical cancer cells. Both in vitro and in vivo evaluations demonstrated the system's potent antitumor efficacy, highlighting its potential as a promising strategy for cervical cancer therapy. |
| WOS关键词 | CERVICAL-CANCER ; CELLS ; GENE ; RESISTANCE ; INDUCTION ; LIPOSOMES ; MONENSIN |
| 资助项目 | National Key Research and Development Program of China[2024YFA1210200] ; National Key Research and Development Program of China[82341232] ; National Key Research and Development Program of China[52203335] ; National Key Research and Development Program of China[82192865] ; National Natural Science Foundation of China[24ZR1477500] ; Natural Science Foundation of Shanghai Municipality[2021B0909050003] ; High-level Innovative Research Institute ; Department of Science and Technology of Guangdong Province[JCYJ20240813115805008] ; Department of Science and Technology of Guangdong Province[ZDSYS201707281114196] ; Shenzhen Science and Technology Innovation Committee[LJ2021001] ; Shenzhen Science and Technology Innovation Committee[CXTD2022011] ; Zhongshan Municipal Bureau of Science and Technology[SZSM202211022] ; Sanming Project of Medicine in Shenzhen[HTHZQSWS-KCCYB-2023060] ; Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001552280900001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321270]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Aihua; Nie, Guohui; Huang, Yongzhuo; Zhang, Bin |
| 作者单位 | 1.Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Pharm, Sch Med, 3rd East Qingchun Rd, Hangzhou 310016, Peoples R China 2.Zhejiang Univ, Ctr Clin Pharmacol, Affiliated Hosp 2, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Peoples R China 3.China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Peoples R China 4.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China 6.Shenzhen Univ, Med Sch,Shenzhen Key Lab Nanozymes & Translat Canc, Shenzhen Peoples Hosp 2,Dept Otolaryngol,Guangdong, Shenzhen Inst Translat Med,Affiliated Hosp 1,Natl, Shenzhen 518035, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhong, Huihai,Fang, Yuefei,Zhao, Pengfei,et al. Co-delivery of TRAIL DNA and salinomycin for cancer therapy via enhanced apoptosis and cancer stemness inhibition[J]. JOURNAL OF MATERIALS CHEMISTRY B,2025,13(35):10926-10937. |
| APA | Zhong, Huihai.,Fang, Yuefei.,Zhao, Pengfei.,Wu, Aihua.,Nie, Guohui.,...&Zhang, Bin.(2025).Co-delivery of TRAIL DNA and salinomycin for cancer therapy via enhanced apoptosis and cancer stemness inhibition.JOURNAL OF MATERIALS CHEMISTRY B,13(35),10926-10937. |
| MLA | Zhong, Huihai,et al."Co-delivery of TRAIL DNA and salinomycin for cancer therapy via enhanced apoptosis and cancer stemness inhibition".JOURNAL OF MATERIALS CHEMISTRY B 13.35(2025):10926-10937. |
入库方式： OAI收割
来源：上海药物研究所
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