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Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

文献类型：期刊论文

作者Yang, Chao9,10; Qiu, Hongling8; Svensson, Sarah L.9,10; Ni, Chengpei7; Gao, Song7; Jia, Zhizhou9,10; Wen, Huiqi9,10; Xie, Li9,10; Xu, Wenxuan9,10; Qin, Yujiao9,10
刊名NATURE ECOLOGY & EVOLUTION
出版日期2025-08-27
页码27
ISSN号2397-334X
DOI10.1038/s41559-025-02827-z
通讯作者Yang, Chao(cyang@siii.cas.cn) ; Martinez-Urtaza, Jaime(Jaime.Martinez.Urtaza@uab.cat) ; Wang, Hui(huiwang@shsmu.edu.cn) ; Falush, Daniel(daniel.falush@siii.cas.cn)
英文摘要While spontaneous mutation and gene acquisition are well-established drivers of pathogen adaptation, the role of gene loss remains underexplored. Here we investigated the emergence and diversification of the pandemic clone of Vibrio parahaemolyticus through large-scale phylogenomic analysis of 8,684 global isolates. The pandemic clone rapidly acquired multiple marker genes and genomic islands, subsequently diverging into successive sublineages mediating independent waves of cross-country transmission, as also observed in Vibrio cholerae. Wave succession in the last two decades was driven by loss of putrescine utilization (Puu) genes, conferring phenotypic advantages for environmental adaptation (enhanced biofilm formation) and human transmission (increased cell adhesion and intestinal colonization and reduced virulence), consistent with the virulence trade-off hypothesis. We identified Puu-gene loss in several bacterial genera, with effects on biofilm and adhesion replicated in V. cholerae and Escherichia coli, suggesting convergent evolution and universal phenotypic effects. Our results highlight the indispensable role of gene loss in bacterial pathogen adaptation.
WOS关键词ESCHERICHIA-COLI ; ANTIVIRULENCE GENES ; BLACK-HOLES ; BACTERIAL ; PATHOGEN ; EVOLUTION ; VIRULENCE ; CHOLERA ; O3-K6 ; INACTIVATION
资助项目National Key Research and Development Program of China[2022YFC2304700] ; National Key Research and Development Program of China[2022YFD2101500] ; National Natural Science Foundation of China[32270003] ; National Natural Science Foundation of China[32000008] ; National Natural Science Foundation of China[32170640] ; National Natural Science Foundation of China[32211550014] ; National Natural Science Foundation of China[32250610209] ; National Natural Science Foundation of China[82030099] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2022278] ; Ministerio de Ciencia e Innovacion (Spain)[PID2021-127107NB-I00] ; Generalitat de Catalunya[2021 SGR 00526] ; Shanghai Rising-Star Program[23QA1410500] ; Shanghai Public Health System Construction Three-Year Action Plan[GWVI-11.1-43] ; Wuxi Science and Technology Development Fund's 'Light of Taihu Lake' Science and Technology Research Program (Basic Research[K20231033] ; Wuxi Science and Technology Development Fund's 'Light of Taihu Lake' Science and Technology Research Program (Basic Research[K20231045] ; Innovative research team of high-level local universities in Shanghai
WOS研究方向Environmental Sciences & Ecology ; Evolutionary Biology
语种英语
WOS记录号WOS:001558934000001
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/321330]  
专题中国科学院上海药物研究所
通讯作者Yang, Chao; Martinez-Urtaza, Jaime; Wang, Hui; Falush, Daniel
作者单位1.Univ Autonoma Barcelona, Dept Genet & Microbiol, Fac Biociencies, Barcelona, Spain
2.Acad Mil Med Sci, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China
3.Natl Key Lab Intelligent Tracking & Forecasting In, Beijing, Peoples R China
4.Soochow Univ, Canc Inst, Suzhou Med Coll, Key Lab Alkene Carbon Fibers Based Technol & Appli, Suzhou, Peoples R China
5.Shenzhen Ctr Dis Control & Prevent, Shenzhen, Peoples R China
6.Nantong Univ, Nantong Peoples Hosp 3, Dept Clin Lab, Affiliated Nantong Hosp 3, Nantong, Peoples R China
7.Nanjing Med Univ, Affiliated Wuxi Ctr Dis Control & Prevent, Wuxi Ctr Dis Control & Prevent, Wuxi, Peoples R China
8.Shanghai Jiao Tong Univ, Sch Med, Ctr Single Cell Om, Sch Publ Hlth,State Key Lab Syst Med Canc, Shanghai, Peoples R China
9.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
10.Chinese Acad Sci, Shanghai Inst Immun & Infect, Ctr Microbes Dev & Hlth, Key Lab Mol Virol & Immunol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Chao,Qiu, Hongling,Svensson, Sarah L.,et al. Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss[J]. NATURE ECOLOGY & EVOLUTION,2025:27.
APA Yang, Chao.,Qiu, Hongling.,Svensson, Sarah L..,Ni, Chengpei.,Gao, Song.,...&Falush, Daniel.(2025).Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss.NATURE ECOLOGY & EVOLUTION,27.
MLA Yang, Chao,et al."Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss".NATURE ECOLOGY & EVOLUTION (2025):27.

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来源：上海药物研究所

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