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Salvianolic Acid B and Ginsenoside Rg1 Combination Attenuates Cerebral Edema Accompanying Glymphatic Modulation

文献类型：期刊论文

作者Zhang, Lingxiao4,5; Shao, Yanan3,4; Fang, Zhao3,4; Chen, Siqi2; Wang, Yixuan3,4; Sha, Han2; Zhang, Yuhan2; Wang, Linlin4; Jin, Yi1; Chen, Hao3,4
刊名NEUROSCIENCE BULLETIN
出版日期2025-08-31
页码15
关键词Cerebral edema Glymphatic system Ischemic stroke SalB/Rg1 MMP9 AQP4
ISSN号1673-7067
DOI10.1007/s12264-025-01490-5
通讯作者Chen, Hao(haoc@simm.ac.cn) ; Jiang, Baohong(jiangbh@simm.ac.cn)
英文摘要Cerebral edema is characterized by fluid accumulation, and the glymphatic system (GS) plays a pivotal role in regulating fluid transport. Using the Tenecteplase system, magnesium salt of salvianolic acid B/ginsenoside Rg1 (SalB/Rg1) was injected intravenously into mice 4.5 h after middle cerebral artery occlusion and once every 24 h for the following 72 h. GS function was assessed by Evans blue imaging, near-infrared fluorescence region II (NIR-II) imaging, and magnetic resonance imaging (MRI). SalB/Rg1 had significant effects on reducing the infarct volume and hemorrhagic transformation score, improving neurobehavioral function, and protecting tissue structure, especially inhibiting cerebral edema. Meanwhile, the influx/efflux drainage of GS was enhanced by SalB/Rg1 according to NIR-II imaging and MRI. SalB/Rg1 inhibited matrix metalloproteinase-9 (MMP-9) activity, reduced cleaved beta-dystroglycan (beta-DG), and stabilized aquaporin-4 (AQP4) polarity, which was verified by colocalization with CD31. Our findings indicated that SalB/Rg1 treatment enhances GS function and attenuates cerebral edema, accompanying the regulation of the MMP9/beta-DG/AQP4 pathway.
WOS关键词ACUTE ISCHEMIC-STROKE ; BETA-DYSTROGLYCAN ; BRAIN EDEMA ; DRAINAGE
资助项目CAS Center for Excellence in Molecular Plant Sciences (Institute of Plant Physiology and Ecology) ; Zhao Guoping Academician Workstation (Hangzhou Academician Workstation) of Zhejiang Chinese Medical University, Chinese Academy of Sciences-the Alliance of National and International Science Organizations for the Belt and Road Regions Fellowship[CAS-ANSO-FP-2024-06] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB1060000] ; Science and Technology Commission of Shanghai Municipality[YDZX20233100004032001]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001560518700001
出版者SPRINGER
源URL[http://119.78.100.183/handle/2S10ELR8/321363]  
专题中国科学院上海药物研究所
通讯作者Chen, Hao; Jiang, Baohong
作者单位1.Shenzhen Testing Ctr Med Devices, Shenzhen Inst Drug Control, Shenzhen 518057, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
5.Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Lingxiao,Shao, Yanan,Fang, Zhao,et al. Salvianolic Acid B and Ginsenoside Rg1 Combination Attenuates Cerebral Edema Accompanying Glymphatic Modulation[J]. NEUROSCIENCE BULLETIN,2025:15.
APA Zhang, Lingxiao.,Shao, Yanan.,Fang, Zhao.,Chen, Siqi.,Wang, Yixuan.,...&Jiang, Baohong.(2025).Salvianolic Acid B and Ginsenoside Rg1 Combination Attenuates Cerebral Edema Accompanying Glymphatic Modulation.NEUROSCIENCE BULLETIN,15.
MLA Zhang, Lingxiao,et al."Salvianolic Acid B and Ginsenoside Rg1 Combination Attenuates Cerebral Edema Accompanying Glymphatic Modulation".NEUROSCIENCE BULLETIN (2025):15.

入库方式： OAI收割

来源：上海药物研究所

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