中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Thiamin hydrochloride (VB1): A green and efficient catalyst for the synthesis of imidazolidin-4-ones

文献类型：期刊论文

作者Liu, Chuang3,4,5; Zhou, Yang3,4; Pei, Wenqiang3,4,5; Hou, Jinjun3,4; Long, Huali3,4; Zhang, Zijia3,4; Chen, Qinhua2; Yang, Yang1; Lei, Min3,4,5; Wu, Wanying3,4,5
刊名SYNTHETIC COMMUNICATIONS
出版日期2025-08-29
页码12
关键词alpha-Aminoamide carbonyl compound green chemistry imidazolidin-4-one thiamin hydrochloride (VB1)
ISSN号0039-7911
DOI10.1080/00397911.2025.2550435
通讯作者Lei, Min(mlei@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn)
英文摘要A green and efficient method for synthesizing imidazolidin-4-one derivatives catalyzed by thiamin hydrochloride (VB1) has been developed. This protocol involves the reaction of alpha-amino amides with carbonyl compounds (aldehydes or ketones) in the presence of VB1 (5 mol%) in EtOH, affording the target products in 50-85% yields. The reaction demonstrates broad substrate compatibility, accommodating aromatic aldehydes, heteroaromatic aldehydes, alkyl aldehydes, and alkyl ketones. Notably, estrone as a ketone substrate successfully undergoes condensation, yielding the corresponding product in 72% yield. The VB1 catalyst offers advantages such as short reaction times, high efficiency, excellent environmental friendliness, and recyclability, maintaining performance over at least three cycles. [GRAPHICS]
资助项目Joint Funds of the National Natural Science Foundation of China[U23A20521] ; Sanming Project of Medicine in Shenzhen[ZZYSM202106004]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001561118200001
出版者TAYLOR & FRANCIS INC
源URL[http://119.78.100.183/handle/2S10ELR8/321366]  
专题中国科学院上海药物研究所
通讯作者Lei, Min; Wu, Wanying
作者单位1.Shenzhen Baoan Authent TCM Therapy Hosp, Key Lab TCM Clin Pharm, Shenzhen, Guangdong, Peoples R China
2.Shenzhen Baoan Authent TCM Therapy Hosp, Shenzhen, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med, Shanghai, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Chuang,Zhou, Yang,Pei, Wenqiang,et al. Thiamin hydrochloride (VB1): A green and efficient catalyst for the synthesis of imidazolidin-4-ones[J]. SYNTHETIC COMMUNICATIONS,2025:12.
APA Liu, Chuang.,Zhou, Yang.,Pei, Wenqiang.,Hou, Jinjun.,Long, Huali.,...&Wu, Wanying.(2025).Thiamin hydrochloride (VB1): A green and efficient catalyst for the synthesis of imidazolidin-4-ones.SYNTHETIC COMMUNICATIONS,12.
MLA Liu, Chuang,et al."Thiamin hydrochloride (VB1): A green and efficient catalyst for the synthesis of imidazolidin-4-ones".SYNTHETIC COMMUNICATIONS (2025):12.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。