中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging

文献类型：期刊论文

作者Jiang, Pu1,2,3; Song, Ruihu1; Hu, Yue1,3; He, Xin1,2,3; Zhang, Zewei1,3; Wei, Xuemei1; Wang, Zhiming1; Guo, De-an2,3; Chen, Hao1,3
刊名ACTA PHARMACEUTICA SINICA B
出版日期2025-08-01
卷号15期号:8页码:4285-4299
关键词Drug side effect Multiplexed imaging Aristolochic acids NIR-II imaging Hemicyanine dyes Liver injuries Kidney injuries Gastric dysfunction
ISSN号2211-3835
DOI10.1016/j.apsb.2025.06.023
通讯作者Wang, Zhiming(zmw@simm.ac.cn) ; Guo, De-an(daguo@simm.ac.cn) ; Chen, Hao(haoC@simm.ac.cn)
英文摘要The precise and rapid monitoring of multiple organ dysfunction is crucial in drug discovery. Traditional methods, such as pathological analysis, are often time-consuming and inefficient. Here, we developed a multiplexed near-infrared window two (NIR-II) fluorescent bioimaging method that allows for real-time, rapid, and quantitative assessment of multiple organ dysfunctions. Given that existing probes did not fully meet requirements, we synthesized a range of NIR-II hemicyanine dyes (HDs) with varying absorption and emission wavelengths. By modifying these dyes, we achieved high spatial and temporal resolution imaging of the liver, kidneys, stomach, and intestines. This method was further applied to investigate disorders induced by cisplatin, a drug known to cause gastric emptying issues along with liver and kidney injuries. By monitoring the metabolic rate of the dyes in these organs, we accurately quantified multi-organ dysfunction, which was also confirmed by gold-standard pathological analysis. Additionally, we evaluated the effects of five aristolochic acids (AAs) on multiple organ dysfunction. For the first time, we identified that AA-I and AA-II could cause gastric emptying disorders, which was further validated through transcriptomics analysis. Our study introduces a novel approach for the simultaneous monitoring of multi-organ dysfunction, which may significantly enhance the evaluation of drug side effects. (c) 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
WOS关键词FLUOROPHORES
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDB1040000] ; National Natural Science Foundation of China[32141005] ; National Natural Science Foundation of China[82071976] ; National Key Research and Development Program of China[2023YFA1800804] ; Science and Technology Innovation Key R&D Program of Chongqing[CSTB2023TIAD-STX0006] ; National Science and Technology Innovation 2030 Major Project of China[2021ZD0203900]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001562025100015
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/321381]  
专题中国科学院上海药物研究所
通讯作者Wang, Zhiming; Guo, De-an; Chen, Hao
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Pu,Song, Ruihu,Hu, Yue,et al. Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging[J]. ACTA PHARMACEUTICA SINICA B,2025,15(8):4285-4299.
APA Jiang, Pu.,Song, Ruihu.,Hu, Yue.,He, Xin.,Zhang, Zewei.,...&Chen, Hao.(2025).Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging.ACTA PHARMACEUTICA SINICA B,15(8),4285-4299.
MLA Jiang, Pu,et al."Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging".ACTA PHARMACEUTICA SINICA B 15.8(2025):4285-4299.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。