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Dual-Channel NIR-II Probe for Simultaneous Tracking of Nitric Oxide and Methylglyoxal in Inflammation: Enabling Rapid Drug Efficacy Assessment

文献类型：期刊论文

作者Cheng, Mengzhen4,5,6; He, Zhong3; Wang, Guannan2; Yu, Yang1; Song, Ruihu3; Qin, Ye3; Wang, Zhiming3; Guo, Dean4,6; Chen, Hao3
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2025-09-17
卷号17期号:37页码:51766-51780
关键词NIR-II responsive probe nitric oxide methylglyoxal T2DM tumor liver injury drug assessment
ISSN号1944-8244
DOI10.1021/acsami.5c11739
通讯作者Wang, Zhiming(zmw@simm.ac.cn) ; Guo, Dean(daguo@simm.ac.cn) ; Chen, Hao(haoc@simm.ac.cn)
英文摘要Nitric oxide (NO) and methylglyoxal (MGO) play a vital part in maintaining redox homeostasis, modulating substances, and signal transduction. Fluctuations in these signaling molecules are closely associated with various pathological processes. However, due to the absence of appropriate multifunctional fluorescent sensors, concurrent identification of NO and MGO has not been achieved in inflammatory diseases. Herein, a dual-responsive near-infrared window II fluorescent probe (TPA-4T) was rationally developed to monitor NO and MGO through its distinct emission channels concurrently. Upon NO exposure, TPA-4T formed the compound TPA-4T-NO with activated fluorescence signals at 980 nm, while MGO oxidation generated TPA-4T-MGO emitting at 1065 nm. This unique dual-responsive imaging property enabled TPA-4T to concurrently monitor the elevated NO and MGO levels in subcutaneous tumors through in vivo imaging for the first time, and the dual-channel visualization in the type 2 diabetes mellitus disease model was achieved. Most importantly, TPA-4T has successfully achieved utility in drug-induced liver injury, enabling not only diagnostic visualization but also rapid drug assessment in vivo. Undoubtedly, compared with single-analyte detection, the dual-biomarker strategy may provide enhanced sensitivity and reliability for inflammation-related disease diagnosis and the screening of therapeutic agents.
WOS关键词GLYCATION END-PRODUCTS ; CANCER ; COMPLICATIONS ; THERAPY ; KIDNEY
资助项目National Natural Science Foundation of China[YDZX20233100004032001] ; Science and Technology Commission of Shanghai Municipality[XDB1040000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[2023YFA1800804] ; National Key Research and Development Program of China[CSTB2023TIAD-STX0006] ; National Key Research and Development Program of China[2021ZD0203900] ; Science and Technology Innovation Key R&D Program of Chongqing[82405022] ; National Natural Science Foundation of China
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001562812500001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/321396]  
专题中国科学院上海药物研究所
通讯作者Wang, Zhiming; Guo, Dean; Chen, Hao
作者单位1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Nucl Med, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Mol Imaging Ctr,State Key Lab Chem Biol, Shanghai 201203, Peoples R China
6.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 210009, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Mengzhen,He, Zhong,Wang, Guannan,et al. Dual-Channel NIR-II Probe for Simultaneous Tracking of Nitric Oxide and Methylglyoxal in Inflammation: Enabling Rapid Drug Efficacy Assessment[J]. ACS APPLIED MATERIALS & INTERFACES,2025,17(37):51766-51780.
APA Cheng, Mengzhen.,He, Zhong.,Wang, Guannan.,Yu, Yang.,Song, Ruihu.,...&Chen, Hao.(2025).Dual-Channel NIR-II Probe for Simultaneous Tracking of Nitric Oxide and Methylglyoxal in Inflammation: Enabling Rapid Drug Efficacy Assessment.ACS APPLIED MATERIALS & INTERFACES,17(37),51766-51780.
MLA Cheng, Mengzhen,et al."Dual-Channel NIR-II Probe for Simultaneous Tracking of Nitric Oxide and Methylglyoxal in Inflammation: Enabling Rapid Drug Efficacy Assessment".ACS APPLIED MATERIALS & INTERFACES 17.37(2025):51766-51780.

入库方式： OAI收割

来源：上海药物研究所

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