New tetrahydrobenzocyclooctabenzofuranone and dibenzocyclooctadiene lignans from Kadsura jaonica
文献类型：期刊论文
| 作者 | Su, Yu4; Shen, Jingjing2,3; Yao, Shuang3; Miao, Lei3; Zhang, Yu3; Zhang, Chuan-Rui1,2,3 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2025-10-01 |
| 卷号 | 186页码:8 |
| 关键词 | Kadsura jaonica Tetrahydrobenzocyclooctabenzofuranone lignans Dibenzocyclooctadiene lignans Epoxy moiety Cytotoxicity Antioxidant activity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2025.106858 |
| 通讯作者 | Zhang, Chuan-Rui(zhangchuanrui@simm.ac.cn) |
| 英文摘要 | Phytochemical investigation of Kadsura japonica led to the isolation and characterization of six new lignans, including four tetrahydrobenzocyclooctabenzofuranone ones designated as kadjaponins A-D (1-4), and two dibenzocyclooctadiene ones named kadjaponins E and F (5 and 6), along with eighteen known analogues (7-24). The structural elucidation of these compounds was achieved through comprehensive spectroscopic analyses, including NMR, MS, and electronic circular dichroism (ECD). Notably, compounds 1 and 2 were found to feature an unprecedented epoxy moiety, prompting the expected structural revisions of three previously reported compounds, heteroclitin J, longipedlignan O, and longipedlignan P. In biological evaluations, compound 20 demonstrated marginal cytotoxicity against HCT-116 human cancer cells (IC50 = 46.6 +/- 2.5 mu M), while compounds 5 and 19-23 exhibited significant ABTS radical scavenging activity, comparable to that of vitamin C used as a positive control. |
| WOS关键词 | SCHISANDRA-CHINENSIS ; SYSTEM ; FRUITS ; STEMS ; HOMOLIGNANS |
| 资助项目 | National Natural Science Foundation of China[22177016] ; Key R & D Program of Shandong Province, China[2024CXPT028] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001565131300005 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321399]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Chuan-Rui |
| 作者单位 | 1.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 4.Chongqing Univ, Coll Comp Sci, Chongqing 400044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Su, Yu,Shen, Jingjing,Yao, Shuang,et al. New tetrahydrobenzocyclooctabenzofuranone and dibenzocyclooctadiene lignans from Kadsura jaonica[J]. FITOTERAPIA,2025,186:8. |
| APA | Su, Yu,Shen, Jingjing,Yao, Shuang,Miao, Lei,Zhang, Yu,&Zhang, Chuan-Rui.(2025).New tetrahydrobenzocyclooctabenzofuranone and dibenzocyclooctadiene lignans from Kadsura jaonica.FITOTERAPIA,186,8. |
| MLA | Su, Yu,et al."New tetrahydrobenzocyclooctabenzofuranone and dibenzocyclooctadiene lignans from Kadsura jaonica".FITOTERAPIA 186(2025):8. |
入库方式： OAI收割
来源：上海药物研究所
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