An undescribed phytyl melilotic acid ester and chromomoric acid derivatives from Artemisia anomala and their cytotoxic and anti-inflammatory activities
文献类型：期刊论文
| 作者 | Meng, Jie2; Miao, Lei4; Yao, Shuang4; Zhang, Yu4; Su, Yu2; Rao, Li2; Li, Guo-Li1; Zhang, Chuan-Rui2,3,4 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2025-10-01 |
| 卷号 | 186页码:6 |
| 关键词 | Artemisia anomala Phytyl melilotic acid ester Chromomoric acid derivatives Quantum chemical calculations Anti-inflammatory activity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2025.106847 |
| 通讯作者 | Li, Guo-Li(liguoli929@163.com) ; Zhang, Chuan-Rui(zhangchuanrui@simm.ac.cn) |
| 英文摘要 | Phytochemical investigation of the ethanol extract from Artemisia anomala twigs and leaves led to the isolation and structural elucidation of four previously unreported compounds, including a phytyl melilotic acid ester designated as artemanoin A (1), and three chromomoric acid derivatives named anomalones E-G (2-4). Their structures, including the absolute configurations, were unambiguously established through extensive spectroscopic characterization (HRESIMS, 1D/2D NMR) coupled with chemical derivatization study and quantum chemical calculations (including ECD, optical rotation and NMR computations). Notably, artemanoin A (1) represents an acyclic diterpenoid featuring an unusual ester linkage with melilotic acid, a structural motif rarely encountered in natural products. In biological evaluations, while none of the isolated compounds exhibited cytotoxic activity against the tested cancer cell lines at concentrations up to 50 mu M, compounds 2-4 demonstrated significant anti-inflammatory potential, showing potent inhibition of NO production in LPS-stimulated RAW264.7 macrophages with IC50 values of 2.81-4.13 mu M. |
| WOS关键词 | DIMERIC GUAIANOLIDES ; SESQUITERPENOIDS |
| 资助项目 | National Natural Science Foundation of China[22177016] ; Key R & D Program of Shandong Province, China[2024CXPT028] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001565131300004 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321402]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Guo-Li; Zhang, Chuan-Rui |
| 作者单位 | 1.Chongqing Three Gorges Med Coll, Chongqing Key Lab Dev & Utilizat Genuine Med Mat T, Chongqing, Peoples R China 2.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Jie,Miao, Lei,Yao, Shuang,et al. An undescribed phytyl melilotic acid ester and chromomoric acid derivatives from Artemisia anomala and their cytotoxic and anti-inflammatory activities[J]. FITOTERAPIA,2025,186:6. |
| APA | Meng, Jie.,Miao, Lei.,Yao, Shuang.,Zhang, Yu.,Su, Yu.,...&Zhang, Chuan-Rui.(2025).An undescribed phytyl melilotic acid ester and chromomoric acid derivatives from Artemisia anomala and their cytotoxic and anti-inflammatory activities.FITOTERAPIA,186,6. |
| MLA | Meng, Jie,et al."An undescribed phytyl melilotic acid ester and chromomoric acid derivatives from Artemisia anomala and their cytotoxic and anti-inflammatory activities".FITOTERAPIA 186(2025):6. |
入库方式： OAI收割
来源：上海药物研究所
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