New Phenanthrene Derivatives and a Flavonoid Glycoside Dihexanoate From Malpighia glabra
文献类型：期刊论文
| 作者 | Fan, Enqi2,3; Yao, Shuang2; Zhang, Yu2; Zhang, Yinan3; Zhang, Chuan Rui1,2 |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2025-09-11 |
| 页码 | 8 |
| 关键词 | configuration determination cytotoxicity flavonoid glycoside Malpighia glabra phenanthrene derivatives |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202502464 |
| 通讯作者 | Zhang, Yinan(yinanzhang@njucm.edu.cn) ; Zhang, Chuan Rui(zhangchuanrui@simm.ac.cn) |
| 英文摘要 | Five previously undescribed compounds, including four rare phenanthrene derivatives, designated as malglabins A-D (1-4), and an unusual flavonoid glycoside dihexanoate, named kaempferol 3-O-(3 '',4 ''-di-O-caproyl)-alpha-L-rhamnopyranoside (5), along with 12 known compounds, were isolated from the leaves and twigs of Malpighia glabra. Their structures (Figure 1) were elucidated through comprehensive spectroscopic analysis (high-resolution electrospray ionization mass spectrometry and one-/two-dimensional nuclear magnetic resonance) complemented by chemical derivatization study and electronic circular dichroism calculations. In biological evaluations, compounds 3 and 4 exhibited weak cytotoxicity against A549 human lung adenocarcinoma cells (IC50 = 34.71 +/- 0.48 and 30.66 +/- 0.67 mu M, respectively), while none of the tested compounds demonstrated anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 macrophages at concentrations up to 50 mu M. |
| WOS关键词 | EMARGINATA DC. ; ANTIOXIDANT ACTIVITY ; ACEROLA ; CONSTITUENTS ; PUNICIFOLIA ; FRUITS ; L. |
| 资助项目 | Key R&D Program of Shandong Province |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001568627800001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321453]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Yinan; Zhang, Chuan Rui |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Peoples R China 3.Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Funct Subst Chinese Med, Nanjing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Enqi,Yao, Shuang,Zhang, Yu,et al. New Phenanthrene Derivatives and a Flavonoid Glycoside Dihexanoate From Malpighia glabra[J]. CHEMISTRY & BIODIVERSITY,2025:8. |
| APA | Fan, Enqi,Yao, Shuang,Zhang, Yu,Zhang, Yinan,&Zhang, Chuan Rui.(2025).New Phenanthrene Derivatives and a Flavonoid Glycoside Dihexanoate From Malpighia glabra.CHEMISTRY & BIODIVERSITY,8. |
| MLA | Fan, Enqi,et al."New Phenanthrene Derivatives and a Flavonoid Glycoside Dihexanoate From Malpighia glabra".CHEMISTRY & BIODIVERSITY (2025):8. |
入库方式： OAI收割
来源：上海药物研究所
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