Distahlianins A-C: Architecturally Diverse Cadinane-Type Sesquiterpenoid Dimers from Stahlianthus involucratus
文献类型：期刊论文
| 作者 | Ji, Kai-Long4; Chen, Yu-Han3; Song, Qin-Qin3; Zheng, Xi-Yu1,4; Sun, Peng4; Lu, Jian-Mei4; Liang, Gang4; Fan, Yao-Yue2,3 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2025-09-26 |
| 卷号 | 27期号:38页码:10843-10848 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.5c03471 |
| 通讯作者 | Ji, Kai-Long(kl14ji@163.com) ; Liang, Gang(lianggang@xtbg.ac.cn) ; Fan, Yao-Yue(s040500290@126.com) |
| 英文摘要 | Three architecturally novel cadinane sesquiterpenoid dimers, distahlianins A-C (1-3), were isolated from Stahlianthus involucratus. Compounds 1 and 2 are characterized by an unusual 5,6-spirocyclic scaffold annulated with oxygenated heterocycles to form intricate 6/6/5/6/6/6 and 6/6/5/5/6/6 hexacyclic frameworks, respectively. Compound 3 features a unique dimeric skeleton formed by two monomeric units bridged through a cyclopentane ring. Intriguingly, structural analysis revealed a unique C14 methyl migration (C-9 -> C-8) in the left monomer unit of 3, representing a new cadinane skeletal feature. Compound 3 exhibited potent lipid-lowering activity, with mechanistic evidence pointing to lipogenesis suppression. |
| WOS关键词 | ADIPOSE-TISSUE ; PARVIFLORENE-A |
| 资助项目 | Chinese Academy of Sciences[202501AT070248] ; Yunnan Fundamental Research Projects[tsqn202408315] ; Taishan Scholars Program[XDB1060000] ; Strategic Priority Research Program of the Chinese Academy of Sciences ; West Light Foundation of Chinese Academy of Sciences[2023T160677] ; China Postdoctoral Science Foundation |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001573366200001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321492]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ji, Kai-Long; Liang, Gang; Fan, Yao-Yue |
| 作者单位 | 1.Yunnan Univ, Sch Agr, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 4.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Kai-Long,Chen, Yu-Han,Song, Qin-Qin,et al. Distahlianins A-C: Architecturally Diverse Cadinane-Type Sesquiterpenoid Dimers from Stahlianthus involucratus[J]. ORGANIC LETTERS,2025,27(38):10843-10848. |
| APA | Ji, Kai-Long.,Chen, Yu-Han.,Song, Qin-Qin.,Zheng, Xi-Yu.,Sun, Peng.,...&Fan, Yao-Yue.(2025).Distahlianins A-C: Architecturally Diverse Cadinane-Type Sesquiterpenoid Dimers from Stahlianthus involucratus.ORGANIC LETTERS,27(38),10843-10848. |
| MLA | Ji, Kai-Long,et al."Distahlianins A-C: Architecturally Diverse Cadinane-Type Sesquiterpenoid Dimers from Stahlianthus involucratus".ORGANIC LETTERS 27.38(2025):10843-10848. |
入库方式： OAI收割
来源：上海药物研究所
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