Advances in small-molecule fluorescent probes for imaging epilepsy biomarkers: A review
文献类型：期刊论文
| 作者 | Rong, Yan7; Zhou, Jiaqi7; Hu, Yuqing7; Chai, Xianzhi6,7; Han, Hai-Hao3,4,5; He, Xiao-Peng1,2 |
| 刊名 | MICROCHEMICAL JOURNAL
 |
| 出版日期 | 2025-11-01 |
| 卷号 | 218页码:13 |
| 关键词 | Reactive oxygen species (ROS) Fluorescent probes Biomarkers. Epilepsy Bioimaging |
| ISSN号 | 0026-265X |
| DOI | 10.1016/j.microc.2025.115238 |
| 通讯作者 | Chai, Xianzhi(chaixianzhi@163.com) ; Han, Hai-Hao(hanhaihao@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) |
| 英文摘要 | Epilepsy is a common neurodegenerative disorder. Despite the rapid development of diagnostic and therapeutic strategies for epilepsy, one-third of patients still suffer from a low diagnostic efficiency due to the substantial heterogeneity of this disease. Therefore, it is imperative to create efficient tools to identify biomarkers expressed during different epileptic states, thereby increasing the number of patients that could benefit from surgical intervention. Fluorescent imaging is an efficient, non-invasive, and high-resolution technique that has emerged as a powerful tool for disease diagnosis. Numerous fluorescent small-molecule probes have been designed for the diagnosis of epilepsy. This review summarizes currently identified biomarkers relevant to epilepsy, and highlights fluorescent probes developed to detect these biomarkers. The use of the probes for fluorescence-based imaging of epilepsy in vivo will also be discussed. Finally, this review discusses the challenges of currently developed fluorescent probes in terms of clinical translation. |
| WOS关键词 | IN-SITU VISUALIZATION ; HYDROGEN-SULFIDE ; FORMALDEHYDE ; BRAIN ; CYTOTOXICITY ; MITOCHONDRIA ; DEFINITION ; OZONE |
| 资助项目 | National Natural Science Foundation of China[22308134] ; National Natural Science Foundation of China[22107029] ; National Natural Science Foundation of China[22377135] ; National Natural Science Foundation of China[92253306] ; National Natural Science Foundation of China[82130099] ; National Natural Science Foundation of China[22477030] ; Natural Science Foundation of Jiangsu Province[BK20220644] ; Postgraduate Research & Practice Innovation Program of Jiangsu Province[KYCX25_4390] ; Taishan Scholars Program[tsqn202312305] ; Young Elite Scientists Sponsorship Program by Chinese Chemical Society ; Fundamental Research Projects of Science & Technology Innovation and Development Plan in Yantai City[2023JCYJ059] ; Shandong Laboratory Program[SYS202205] ; Key R&D Program of Shandong[2024CXPT028] ; Science and Technology Commission of Shanghai Municipality[24DX1400200] ; International Cooperation Program of Shanghai Science and Technology[23490711600] ; Ministry of Education Key Laboratory on signaling Regulation and Targeting Therapy of Liver Cancer (Naval Medical University) ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; Open Funding Project of the State Key Laboratory of Bioreactor Engineering ; State Key Laboratory of Drug Research[SKLDR-2023-KF-10] ; State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, P. R. China ; [2023-MEKLLC-MS/ZD-00*] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001571755900001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321498]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chai, Xianzhi; Han, Hai-Hao; He, Xiao-Peng |
| 作者单位 | 1.Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China 2.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat & Joint Int Re, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Stake Key Lab Chem Biol, Shanghai 201203, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 6.Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200438, Peoples R China 7.Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang 212100, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Rong, Yan,Zhou, Jiaqi,Hu, Yuqing,et al. Advances in small-molecule fluorescent probes for imaging epilepsy biomarkers: A review[J]. MICROCHEMICAL JOURNAL,2025,218:13. |
| APA | Rong, Yan,Zhou, Jiaqi,Hu, Yuqing,Chai, Xianzhi,Han, Hai-Hao,&He, Xiao-Peng.(2025).Advances in small-molecule fluorescent probes for imaging epilepsy biomarkers: A review.MICROCHEMICAL JOURNAL,218,13. |
| MLA | Rong, Yan,et al."Advances in small-molecule fluorescent probes for imaging epilepsy biomarkers: A review".MICROCHEMICAL JOURNAL 218(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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