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Design and evaluation of cyanocobalamin nasal powders for nasal delivery using biomimetic nasal cavity models

文献类型：期刊论文

作者Lv, Yuting1,6,7; Li, Zeru5,6; Wu, Qian4,6; Peng, Ningning1,4,6; Gao, Qingfang1,4,6; Xu, Huipeng6; Shao, Shuang1,3,6; Zhao, Xia2; Gui, Shuangying7; Zhang, Jiwen3,4,5,6,7
刊名JOURNAL OF PHARMACEUTICAL SCIENCES
出版日期2025-11-01
卷号114期号:11页码:13
关键词Vitamin B12 Hydroxypropyl-beta-cyclodextrin Nasal powder Nasal drug delivery Powder technology Nasal cavity model 3D Printing Nasal absorption Bioavailability
ISSN号0022-3549
DOI10.1016/j.xphs.2025.103996
通讯作者Wang, Caifen(wangcaifen@simm.ac.cn) ; Yang, Rui(yangr@nifdc.org.cn) ; Wu, Li(wuli@simm.ac.cn)
英文摘要For intranasal administration, biomimetic evaluation in vitro plays a unique role in visualizing drug deposition in the nasal cavity, guiding the pharmacokinetic test. In this study, cyanocobalamin (Vitamin B12, VB12) nasal powders were developed and evaluated based on the biomimetic rat and human nasal models. Hydroxypropyl beta-cyclodextrin (HP-beta-CD) was selected as a carrier to improve photostability and thermal stability of VB12. The nasal mucosal permeation study confirmed the permeation promotion of HP-beta-CD to VB12. To assess nasal deposition patterns, three-dimensional (3D) printed rat and human nasal cavity models were developed based on computed tomography (CT) images. The rat nasal cavity model was also used to evaluate self-designed nozzles tailored to nasal cavity structures, which significantly reduced tracheal deposition when administered at an optimized angle. In the rat nasal cavity model, the powders were primarily deposited in the olfactory zone (38.85 +/- 3.90%), while in the human nasal cavity model, deposition was predominantly in the respiratory zone (69.12 +/- 6.38%). Pharmacokinetics in rats showed that the nasal powders exhibited good bioavailability (36.45%) compared with nasal and gavage solutions. Additionally, nasal cavity drug retention studies indicated superior retention of the nasal powder compared with the VB12 nasal solution. In summary, VB12 nasal powder was visualized using 3D biomimetic nasal models and effectively delivered to the nasal cavity in rats, providing a reference for evaluating nasal powder and other nasal dosage forms.
WOS关键词IN-VIVO EVALUATION ; BETA-CYCLODEXTRIN ; VITAMIN-B-12 ; BIOAVAILABILITY ; ABSORPTION ; PHARMACOKINETICS ; MICROPARTICLES ; FORMULATION
资助项目Natural Science Foundation of China[Ndegrees82273863]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:001578643100001
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/321576]  
专题中国科学院上海药物研究所
通讯作者Wang, Caifen; Yang, Rui; Wu, Li
作者单位1.Jiangsu Yungou Pharmaceut Technol Co Ltd, Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China
2.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
3.Jiangxi Univ Chinese Med, Nanchang 330004, Peoples R China
4.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
5.Nanjing Univ Chinese Med, Nanjing 210023, Peoples R China
6.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China
7.Anhui Univ Chinese Med, Hefei 230000, Peoples R China
推荐引用方式
GB/T 7714		 Lv, Yuting,Li, Zeru,Wu, Qian,et al. Design and evaluation of cyanocobalamin nasal powders for nasal delivery using biomimetic nasal cavity models[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2025,114(11):13.
APA Lv, Yuting.,Li, Zeru.,Wu, Qian.,Peng, Ningning.,Gao, Qingfang.,...&Wu, Li.(2025).Design and evaluation of cyanocobalamin nasal powders for nasal delivery using biomimetic nasal cavity models.JOURNAL OF PHARMACEUTICAL SCIENCES,114(11),13.
MLA Lv, Yuting,et al."Design and evaluation of cyanocobalamin nasal powders for nasal delivery using biomimetic nasal cavity models".JOURNAL OF PHARMACEUTICAL SCIENCES 114.11(2025):13.

入库方式： OAI收割

来源：上海药物研究所

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