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Deaminative Functionalization of Olefins and Dienes with Katritzky Salts: A Highly Selective Route to Diverse Deuterium-Labeled Molecules

文献类型：期刊论文

作者Sajjad, Farrukh4; Zhou, Guanfeng3; Yan, Congyin3; Shen, Bingjie3; Liu, Hanfu4; Xu, Wen3; Zheng, Xinni4; Lu, Cheng2; Chen, Tie-Gen1,3,4
刊名ORGANIC LETTERS
出版日期2025-10-17
卷号27期号:41页码:11543-11548
ISSN号1523-7060
DOI10.1021/acs.orglett.5c03565
通讯作者Lu, Cheng(luchengjy@ust.hk) ; Chen, Tie-Gen(chentiegen@simm.ac.cn)
英文摘要Herein, we report a deaminative alkylation of olefins, followed by deuteration that allows the formation of sp3-sp3 architectures. This protocol enables the previously unexploited functionalization of dienes with pyridinium salts, providing rapid access to complex molecules from bulk chemicals in a highly selective manner. Notably, the diversification of commercially available drug molecules particularly through deuteration is widely recognized as an effective strategy for drug discovery. Gratifyingly, this reaction facilitated the alkylation of drug- and amino acid-derived pyridinium salts, demonstrating both its synthetic versatility and potential utility in drug development.
WOS关键词3-COMPONENT DICARBOFUNCTIONALIZATION ; COUPLINGS
资助项目The 100 Talents Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China[22371303] ; Science and Technology Commission of Shanghai Municipality[23ZR1474300] ; Zhongshan Municipal Bureau of Science and Technology[2021B2014] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022013] ; Shanghai Rising-Star Program[21QA1411000]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001588957500001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/321615]  
专题中国科学院上海药物研究所
通讯作者Lu, Cheng; Chen, Tie-Gen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong 999077, Peoples R China
3.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
推荐引用方式
GB/T 7714		 Sajjad, Farrukh,Zhou, Guanfeng,Yan, Congyin,et al. Deaminative Functionalization of Olefins and Dienes with Katritzky Salts: A Highly Selective Route to Diverse Deuterium-Labeled Molecules[J]. ORGANIC LETTERS,2025,27(41):11543-11548.
APA Sajjad, Farrukh.,Zhou, Guanfeng.,Yan, Congyin.,Shen, Bingjie.,Liu, Hanfu.,...&Chen, Tie-Gen.(2025).Deaminative Functionalization of Olefins and Dienes with Katritzky Salts: A Highly Selective Route to Diverse Deuterium-Labeled Molecules.ORGANIC LETTERS,27(41),11543-11548.
MLA Sajjad, Farrukh,et al."Deaminative Functionalization of Olefins and Dienes with Katritzky Salts: A Highly Selective Route to Diverse Deuterium-Labeled Molecules".ORGANIC LETTERS 27.41(2025):11543-11548.

入库方式： OAI收割

来源：上海药物研究所

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