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Rhodium-Catalyzed C-H Heteroarylation and Alkenylation of N-Phenoxyacetamides Using Iodonium Ylides

文献类型：期刊论文

作者Ding, Wenqian4,5; Hu, Wanqi3,4; Liu, Weiqi1,2; Wu, Xiaowei1,2,3,4,5
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2025-10-17
卷号90期号:41页码:14373-14382
ISSN号0022-3263
DOI10.1021/acs.joc.5c00858
通讯作者Wu, Xiaowei(wuxiaowei@simm.ac.cn)
英文摘要Herein, we describe a rhodium-catalyzed monoheteroarylation and alkenylation of N-phenoxyacetamides using iodonium ylides derived from cyclo-1,3-diones. This approach efficiently delivers novel heteroarylated and alkenylated products under mild reaction conditions. The protocol showcases good functional group tolerance and a wide substrate scope. Furthermore, this allows for smooth scale-up synthesis. Additional transformation experiments were conducted to highlight the potential synthetic utility of this methodology.
WOS关键词PHENOLS ; FUNCTIONALIZATION ; CARBOAMINATION ; ALKYNYLATION ; ACTIVATION ; ARYLATION ; ALKYNES ; MILD
资助项目National Natural Science Foundation of China[82404416] ; National Natural Science Foundation of China[CXTD2023009] ; Zhongshan Science and Technology Bureau
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001587995900001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/321621]  
专题中国科学院上海药物研究所
通讯作者Wu, Xiaowei
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
5.Guangzhou Univ Chinese Med, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Ding, Wenqian,Hu, Wanqi,Liu, Weiqi,et al. Rhodium-Catalyzed C-H Heteroarylation and Alkenylation of N-Phenoxyacetamides Using Iodonium Ylides[J]. JOURNAL OF ORGANIC CHEMISTRY,2025,90(41):14373-14382.
APA Ding, Wenqian,Hu, Wanqi,Liu, Weiqi,&Wu, Xiaowei.(2025).Rhodium-Catalyzed C-H Heteroarylation and Alkenylation of N-Phenoxyacetamides Using Iodonium Ylides.JOURNAL OF ORGANIC CHEMISTRY,90(41),14373-14382.
MLA Ding, Wenqian,et al."Rhodium-Catalyzed C-H Heteroarylation and Alkenylation of N-Phenoxyacetamides Using Iodonium Ylides".JOURNAL OF ORGANIC CHEMISTRY 90.41(2025):14373-14382.

入库方式： OAI收割

来源：上海药物研究所

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