Photo-assisted four-component one-pot assembly of a branched heptasaccharide derived from Carthamus tinctorius
文献类型：期刊论文
| 作者 | Hu, Chaoyu2; Wu, Ruixue2; Ni, Xiang2; Ma, Wenjing2; Hao, Tianhui2; Xu, Zhuojia2; Ding, Kan1,2; Li, Tiehai2 |
| 刊名 | JOURNAL OF CARBOHYDRATE CHEMISTRY
 |
| 出版日期 | 2025-10-04 |
| 页码 | 16 |
| 关键词 | Oligosaccharide synthesis photo-assisted synthesis one-pot glycan assembly glycosylation |
| ISSN号 | 0732-8303 |
| DOI | 10.1080/07328303.2025.2568841 |
| 通讯作者 | Ding, Kan(dingkan@simm.ac.cn) ; Li, Tiehai(tiehaili@gmail.com) |
| 英文摘要 | A photo-assisted oligosaccharide assembly strategy is reported for the facile synthesis of a branched heptasaccharide with potential anti-panceratic cancer activity in a four-component [2 + 1 + 1 + 3] one-pot coupling manner. A key feature of this strategy is the incorporation of photocleavable o-nitrobenzyl group-protected saccharide building blocks. Upon exposure to ultraviolet radiation, these blocks can generate in situ the corresponding acceptors for subsequent glycosylations without the purification step, thereby facilitating the one-pot coupling process and enabling the rapid assembly of the heptasaccharide. |
| WOS关键词 | CHEMICAL-SYNTHESIS ; OLIGOSACCHARIDE ; PREACTIVATION ; ANTIGEN |
| 资助项目 | National Natural Science Foundation of China[22377134] ; National Natural Science Foundation of China[32271332] ; China Postdoctoral Science Foundation[2023M743658] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001587565700001 |
| 出版者 | TAYLOR & FRANCIS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321639]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ding, Kan; Li, Tiehai |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Chaoyu,Wu, Ruixue,Ni, Xiang,et al. Photo-assisted four-component one-pot assembly of a branched heptasaccharide derived from Carthamus tinctorius[J]. JOURNAL OF CARBOHYDRATE CHEMISTRY,2025:16. |
| APA | Hu, Chaoyu.,Wu, Ruixue.,Ni, Xiang.,Ma, Wenjing.,Hao, Tianhui.,...&Li, Tiehai.(2025).Photo-assisted four-component one-pot assembly of a branched heptasaccharide derived from Carthamus tinctorius.JOURNAL OF CARBOHYDRATE CHEMISTRY,16. |
| MLA | Hu, Chaoyu,et al."Photo-assisted four-component one-pot assembly of a branched heptasaccharide derived from Carthamus tinctorius".JOURNAL OF CARBOHYDRATE CHEMISTRY (2025):16. |
入库方式： OAI收割
来源：上海药物研究所
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