Uncommon 4-methylpregnane and anti-inflammatory 5α,8α-epidioxysterols from the South China Sea soft coral Sarcophyton sp.
文献类型：期刊论文
| 作者 | Zhu, Sheng-Hui2; Gong, Qi3; Li, Song-Wei2; Zhang, Hai-Yan3; Guo, Yue-Wei1,2 |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2025-11-01 |
| 卷号 | 239页码:6 |
| 关键词 | Soft coral Sarcophyton Steroid Structural elucidation Anti-inflammatory activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2025.114586 |
| 英文摘要 | One uncommon 4-methylpregnane-type steroid (1), four previously undescribed 5 alpha,8 alpha-epidioxysterols (3-6), along with two known compounds (2 and 7), were isolated from the Chinese soft coral Sarcophyton sp. A distinguishing feature of 3-6 was the presence of a rare 1,2-dioxane ring system, which has not been frequently reported in the steroids from Sarcophyton genus. Their structures were determined by extensive spectroscopic analysis, comparison with the spectral data reported in the literature and X-ray diffraction analysis. In in vitro bioassays, compounds 3-6 exhibited significant anti-inflammatory activities, with the peroxide bridge in the Bring hypothesized to play a key role in these effects. The results underscore the therapeutic potential of marinederived steroidal compounds, particularly for the treatment of inflammatory diseases. This study highlights the South China Sea soft corals as a valuable resource for bioactive compounds and offers new directions for drug discovery in the field of anti-inflammatory therapies. |
| WOS关键词 | ERGOSTEROL PEROXIDE ; SPONGE |
| 资助项目 | Key R & D Program of Shandong Province, China[2024CXPT029] ; National Natural Science Foundation of China (NSFC)[82304375] ; National Key Research and Development Program of China[2022YFC2804100] ; Shandong Laboratory Program[SYS202205] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001527091200001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318825]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Li, Song-Wei; Zhang, Hai-Yan; Guo, Yue-Wei |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 2.Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Sheng-Hui,Gong, Qi,Li, Song-Wei,et al. Uncommon 4-methylpregnane and anti-inflammatory 5α,8α-epidioxysterols from the South China Sea soft coral Sarcophyton sp.[J]. PHYTOCHEMISTRY,2025,239:6. |
| APA | Zhu, Sheng-Hui,Gong, Qi,Li, Song-Wei,Zhang, Hai-Yan,&Guo, Yue-Wei.(2025).Uncommon 4-methylpregnane and anti-inflammatory 5α,8α-epidioxysterols from the South China Sea soft coral Sarcophyton sp..PHYTOCHEMISTRY,239,6. |
| MLA | Zhu, Sheng-Hui,et al."Uncommon 4-methylpregnane and anti-inflammatory 5α,8α-epidioxysterols from the South China Sea soft coral Sarcophyton sp.".PHYTOCHEMISTRY 239(2025):6. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。