Antimalarial spirooxindole alkaloids with a rare 6/5/5/6/6 polycyclic skeleton from the fungus Penicillium citrinum YSC-1 isolated from a medicinal plant
文献类型：期刊论文
| 作者 | Wu, Pei-Qian1; Zhou, Jun-Su1; Do Amaral, Leticia S.2,3; Cassera, Maria B.2,3; Yue, Jian-Min1; Zhou, Bin1 |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2025-09-01 |
| 卷号 | 164页码:13 |
| 关键词 | Penicillium citrinum YSC-1 Spirooxindole alkaloids OSMAC Plasmodium falciparum Dd2 Stage-specific assay |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2025.108825 |
| 英文摘要 | OSMAC (one strain many compounds) provides a convenient strategy to produce chemically diverse and novel natural products. In the study, the application of an OSMAC approach on a fungus Penicillium citrinum YSC-1 isolated from a medicinal plant Chloranthus japonicus, using different culture media, led to the isolation and identification of seven new spirooxindole alkaloids penicitrimicins A-G (1-7) with a rare 6/5/5/6/6 polycyclic skeleton, along with two known compounds (8-9). The new structures were characterized based on the comprehensive spectroscopic analyses, including 1D, 2D NMR and HRESIMS data. The absolute configurations of compounds 1-7 were determined by modified Mosher ester methodology, PGME derivatization, X-ray crystallographic analysis, and quantum chemical calculations. Biological evaluation revealed that these spirooxindole alkaloids exhibited good biocompatibility (<5 % hemolysis and > 80 % cell viability) while displaying obvious antimalarial activity against Plasmodium falciparum Dd2 strain, with EC50 values spanning 0.9-2.4 mu M. Furthermore, stage-specific assays revealed that compound 5 displayed significant inhibitory effects on the developmental transition of asexual blood-stage parasites, effectively blocking their progression to subsequent lifecycle stages. |
| 资助项目 | National Natural Science Foundation of China[82322064] ; National Natural Science Foundation of China[22177122] ; Shanghai Rising-Star Program[24QA2711300] ; SANOFI Scholarship Program ; Technique College of Agriculture and Forestry, Longnan Normal University |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001609109600003 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/319804]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Yue, Jian-Min; Zhou, Bin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA 3.Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA |
| 推荐引用方式 GB/T 7714 | Wu, Pei-Qian,Zhou, Jun-Su,Do Amaral, Leticia S.,et al. Antimalarial spirooxindole alkaloids with a rare 6/5/5/6/6 polycyclic skeleton from the fungus Penicillium citrinum YSC-1 isolated from a medicinal plant[J]. BIOORGANIC CHEMISTRY,2025,164:13. |
| APA | Wu, Pei-Qian,Zhou, Jun-Su,Do Amaral, Leticia S.,Cassera, Maria B.,Yue, Jian-Min,&Zhou, Bin.(2025).Antimalarial spirooxindole alkaloids with a rare 6/5/5/6/6 polycyclic skeleton from the fungus Penicillium citrinum YSC-1 isolated from a medicinal plant.BIOORGANIC CHEMISTRY,164,13. |
| MLA | Wu, Pei-Qian,et al."Antimalarial spirooxindole alkaloids with a rare 6/5/5/6/6 polycyclic skeleton from the fungus Penicillium citrinum YSC-1 isolated from a medicinal plant".BIOORGANIC CHEMISTRY 164(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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