Mycobacterial Tyrosine Phosphatase PtpB Affects Host Cytokine Expression by Dephosphorylating ERK1/2 and STAT3
文献类型：期刊论文
| 作者 | Liu, Tianxian1,2; Fan, Yameng2; Chen, Yijia; Xie, Shuyu2; Xu, Jun-Yu2,3; Tan, Minjia2,3; Ye, Bang-Ce1 |
| 刊名 | MOLECULAR & CELLULAR PROTEOMICS
 |
| 出版日期 | 2025-10-01 |
| 卷号 | 24期号:10页码:17 |
| DOI | 10.1016/j.mcpro.2025.101067 |
| 英文摘要 | Mycobacterium tuberculosis (Mtb) tyrosine phosphatases PtpA and PtpB have been widely reported to affect host immunity response and bacterial intercellular survival. However, a comprehensive investigation into the impact of PtpA and PtpB on host phosphorylation, specifically in their roles as tyrosine phosphatases, has not yet been reported. In this study, we first conducted the potential dephosphorylation substrates map of PtpA and PtpB within the host. Our findings demonstrated that PtpB significantly decreased the phosphorylation levels of ERK1/2 and STAT3. Subsequent analysis indicated that PtpB modulated the production of cytokine TNF and IL-1 beta by dephosphorylating ERK1/2 and preventing its nuclear translocation. PtpB also reduced IL-6 and IL-1 beta expression by dephosphorylating STAT3. The in vivo experiment demonstrated increased bacterial survival and reduced cytokine expression in the PtpB-overexpression strain. Consequently, our findings demonstrate that Mtb tyrosine phosphatases PtpA and PtpB play critical roles in the global tyrosine phosphorylation landscape within the host. Specifically, PtpB modulates cytokine expression through the dephosphorylation of ERK1/2 and STAT3. |
| WOS关键词 | TUBERCULOSIS ; SURVIVAL ; KINASE |
| 资助项目 | National Natural Science Foundation of China[22134003] ; National Natural Science Foundation of China[22225702] ; National Natural Science Foundation of China[T2488301] ; National Natural Science Foundation of China[32322048] ; Program of Shanghai Academic Research Leader[22XD1420900] ; National Key Research and Development Program of China[2023YFA1800403] ; Innovative Research Team of High-Level Local Universities in Shanghai[SHSMU-ZDCX20212700] ; Young Elite Scientists Sponsorship Program by CAST[2022QNRC001] ; Shanghai Rising-Star Program[22QA1411100] ; Youth Innovation Promotion Association[CAS2021276] ; Sanofi scholarship pro-gram ; Guangdong High-level New R&D Institute, China[:2019B090904008] ; Guangdong High-level Innovative Research Institute, China[:2021B0909050003] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001593370700001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/320661]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Xu, Jun-Yu; Tan, Minjia; Ye, Bang-Ce |
| 作者单位 | 1.East China Univ Sci & Technol, Lab Biosyst & Microanal, State Key Lab Bioreactor Engn, Shanghai, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Tianxian,Fan, Yameng,Chen, Yijia,et al. Mycobacterial Tyrosine Phosphatase PtpB Affects Host Cytokine Expression by Dephosphorylating ERK1/2 and STAT3[J]. MOLECULAR & CELLULAR PROTEOMICS,2025,24(10):17. |
| APA | Liu, Tianxian.,Fan, Yameng.,Chen, Yijia.,Xie, Shuyu.,Xu, Jun-Yu.,...&Ye, Bang-Ce.(2025).Mycobacterial Tyrosine Phosphatase PtpB Affects Host Cytokine Expression by Dephosphorylating ERK1/2 and STAT3.MOLECULAR & CELLULAR PROTEOMICS,24(10),17. |
| MLA | Liu, Tianxian,et al."Mycobacterial Tyrosine Phosphatase PtpB Affects Host Cytokine Expression by Dephosphorylating ERK1/2 and STAT3".MOLECULAR & CELLULAR PROTEOMICS 24.10(2025):17. |
入库方式： OAI收割
来源：上海药物研究所
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