Bacteriophage-mediated antibacterial and photodynamic therapies
文献类型：期刊论文
| 作者 | Yu, Rui1,4,5; Li, Guo-Bo6; Ye, Bengui6,7; Kim, Jong Seung8; Hong, Xuechuan1,2,3; Xiao, Yuling3,4,5; Zeng, Xiaodong4 |
| 刊名 | RSC MEDICINAL CHEMISTRY
 |
| 出版日期 | 2025-10-08 |
| 页码 | 13 |
| DOI | 10.1039/d5md00669d |
| 英文摘要 | Antimicrobial resistance threatens global health, with multidrug-resistant pathogens causing millions of deaths annually. Conventional antibiotics face limitations due to bacterial biofilms, resistance mechanisms, and host toxicity. Bacteriophages, due to their high specificity, hold great potential in antimicrobial therapy, targeted drug delivery. In recent years, advances in chemical biology and nanomaterials science have led to the continuous refinement of surface chemical modification strategies for bacteriophage capsids, providing robust support for their functional expansion. This review summarizes commonly employed bacteriophage surface modification techniques, including both covalent and non-covalent approaches, and categorizes various types of photosensitizers along with their recent progress in antimicrobial applications. Furthermore, it highlights recent studies on bacteriophage-photodynamic synergistic therapy systems in treating bacterial infections and discusses their application prospects and future directions in the field of precision antimicrobial therapy. |
| WOS关键词 | PHAGE ; RESISTANCE ; PHOTOSENSITIZERS ; PHTHALOCYANINE ; DISCOVERY ; SYSTEM ; ACID |
| 资助项目 | Taishan Scholar Project of Shandong Province[W2511012] ; NSFC Key International (Regional) Joint Research Program[2023YFC3605500] ; National Key R&D Program of China[22477129] ; National Key R&D Program of China[82273796] ; National Natural Science Foundation of China[JCYJ20220530140605012] ; National Natural Science Foundation of China[JCYJ20230807090100002] ; National Natural Science Foundation of China[JCYJ20240813111300001] ; Shenzhen Science and Technology Research Grant[2023A1515012649] ; Guangdong Basic and Applied Basic Research Foundation[TSQN202306320] ; Taishan Scholar Project of Shandong Province[XZ202301ZY0014G] ; Taishan Scholar Project of Shandong Province[LSKJ202445] ; Tibet Autonomous Region Science and Technology Plan Project Key Project[ZR2023MB085] ; Natural Science Foundation of Shandong Province[SYS202205] ; Shandong Laboratory Program |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001595298600001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/320667]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Kim, Jong Seung; Hong, Xuechuan; Xiao, Yuling; Zeng, Xiaodong |
| 作者单位 | 1.Tibet Univ, Sch Ecol & Environm, Key Lab Biodivers & Environm Qinghai Tibetan Plate, Minist Educ, Lhasa 850000, Peoples R China 2.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Radiol, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 5.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China 6.Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist,Sichuan Engn Lab Plant Sourced Drug Pr, Chengdu 610041, Peoples R China 7.Tibet Univ, Med Coll, Lhasa 850002, Peoples R China 8.Korea Univ, Dept Chem, Seoul 02841, South Korea |
| 推荐引用方式 GB/T 7714 | Yu, Rui,Li, Guo-Bo,Ye, Bengui,et al. Bacteriophage-mediated antibacterial and photodynamic therapies[J]. RSC MEDICINAL CHEMISTRY,2025:13. |
| APA | Yu, Rui.,Li, Guo-Bo.,Ye, Bengui.,Kim, Jong Seung.,Hong, Xuechuan.,...&Zeng, Xiaodong.(2025).Bacteriophage-mediated antibacterial and photodynamic therapies.RSC MEDICINAL CHEMISTRY,13. |
| MLA | Yu, Rui,et al."Bacteriophage-mediated antibacterial and photodynamic therapies".RSC MEDICINAL CHEMISTRY (2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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