Recent progress in histone post-translational modifications as regulators of metabolic diseases: A review
文献类型：期刊论文
| 作者 | Zhu, Aiqiang1,2; Ye, Tong1,3; Tan, Minjia1,2,3; Xu, Jun-Yu1,2,3,4 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2025-11-01 |
| 卷号 | 330页码:23 |
| 关键词 | PTMs Metabolic diseases Epigenetics Detection methods Pharmacological interventions |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2025.147964 |
| 英文摘要 | Histone post-translational modifications (PTMs) are epigenetic mechanisms that regulate protein activity, localization, and gene expression by altering chromatin states. Through individual or synergistic effects, PTMs dynamically modulate protein functions, contributing to metabolic homeostasis and disease pathogenesis. Recent advances in mass spectrometry (MS)-based proteomics, particularly liquid chromatography-tandem mass spectrometry (LC-MS/MS) platforms, have enabled systematic mapping of PTM dynamics. Building on these technological advancements, this review comprehensively classifies PTM types, elucidates their roles in diseaseassociated signaling pathways, and discusses cutting-edge detection methods. Furthermore, we highlight therapeutic strategies targeting PTMs, offering new insights into drug development for metabolic dysregulation. Integrating mechanistic insights with clinical applications, this work informs the rational development of future PTM-targeted interventions. |
| WOS关键词 | OXIDATIVE STRESS ; GENE-EXPRESSION ; LYSINE 2-HYDROXYISOBUTYRYLATION ; MODIFICATION PATTERNS ; ALZHEIMERS-DISEASE ; MASS-SPECTROMETRY ; STRUCTURAL BASIS ; YEATS DOMAIN ; PROTEIN ; ACETYLATION |
| 资助项目 | National Natural Science Foundation of China[32322048] ; National Natural Science Foundation of China[32471497] ; Shanghai Rising-Star Program[22QA1411100] ; National Key Research and Development Program of China[2023YFA1800400] ; National Key Research and Development Program of China[2023YFA1800403] ; Zhongshan Science and Technology Bureau[CXTD2024006] ; Program of Shanghai Academic Research Leader[22XD1420900] ; Young Elite Scientists Sponsorship Program by CAST[2022QNRC001] ; Youth Innovation Promotion Association[CAS2021276] ; Sanofi scholarship program ; Guangdong High-level New R & D Institute, China[:2019B090904008] ; Guangdong High-level Innovative Research Institute, China[2021B0909050003] ; Innovative research team of high-level local universities in Shanghai |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001592467700006 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/320721]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Tan, Minjia; Xu, Jun-Yu |
| 作者单位 | 1.Shanghai Inst Mat Med, Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Chinese Acad Sci, Zhongshan 528400, Guangdong, Peoples R China 4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Aiqiang,Ye, Tong,Tan, Minjia,et al. Recent progress in histone post-translational modifications as regulators of metabolic diseases: A review[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,330:23. |
| APA | Zhu, Aiqiang,Ye, Tong,Tan, Minjia,&Xu, Jun-Yu.(2025).Recent progress in histone post-translational modifications as regulators of metabolic diseases: A review.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,330,23. |
| MLA | Zhu, Aiqiang,et al."Recent progress in histone post-translational modifications as regulators of metabolic diseases: A review".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 330(2025):23. |
入库方式： OAI收割
来源：上海药物研究所
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