A Dendritic Cell-Nanogel Conjugate for Tumor-Draining Lymph Node-Specific PD-L1 Blockade
文献类型：期刊论文
| 作者 | Yi, Wenzhe1,2,4; Qian, Xindi1,2; Yan, Dan1,2; Yan, Wenlu1,2,4; Hu, Shuangshuang1,2,5; Li, Yaping1,2,4,6; Wang, Dangge3 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2025-07-07 |
| 页码 | 16 |
| 关键词 | anti-PD-L1 antibody dendritic cells immunotherapy tumor-derived lymph nodes |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202504733 |
| 英文摘要 | Targeted blockade of immune checkpoints within tumor-draining lymph nodes (TDLNs) represents a promising strategy to potentiate immune checkpoint blockade (ICB) therapy. However, the limited delivery of checkpoint inhibitors to TDLNs and inadequate T cell priming persist as major challenges. In this study, an innovative dendritic cell (DC)-based strategy is developed for the targeted delivery of ICB antibodies to TDLNs. The platform is fabricated by conjugating anti-PD-L1 antibody nanogels with DCs, which are further enhanced by pre-treating DCs with tumor antigens. Subcutaneous administration enabled DCs to execute their intrinsic TDLN-tropic migration, thus facilitating antibody delivery and release under reductive conditions. The antigen-loaded DCs mobilized T cell immunity, while the anti-PD-L1 antibodies block PD-L1 on dendritic cells and myeloid cells within TDLNs, thereby augmenting systemic antitumor immunity. This approach significantly suppresses breast cancer growth, leading to 83.3% of treated mice being tumor-free. This study presents a novel strategy for TDLN-targeted PD-L1 blockade by harnessing the intrinsic TDLN tropism of DCs, unveiling new translational opportunities of combining DC-based vaccination with ICB therapy. |
| WOS关键词 | CANCER-IMMUNOTHERAPY ; IMMUNITY ; DELIVERY |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Grant ; Shanghai Advanced Research Institute, Chinese Academy of Sciences, China ; National Natural Science Foundation of China[32130058] ; National Natural Science Foundation of China[32170935] ; National Key R&D Program of China[2022YFC3401404] ; Science and Technology Commission of Shanghai Municipality[24J22800600] ; Shandong Laboratory Program[SYS202205] ; [XDC0290302] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001523660100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321036]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Li, Yaping; Wang, Dangge |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Precis Res Ctr Refractory Dis, Shanghai 201620, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China 6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yi, Wenzhe,Qian, Xindi,Yan, Dan,et al. A Dendritic Cell-Nanogel Conjugate for Tumor-Draining Lymph Node-Specific PD-L1 Blockade[J]. ADVANCED MATERIALS,2025:16. |
| APA | Yi, Wenzhe.,Qian, Xindi.,Yan, Dan.,Yan, Wenlu.,Hu, Shuangshuang.,...&Wang, Dangge.(2025).A Dendritic Cell-Nanogel Conjugate for Tumor-Draining Lymph Node-Specific PD-L1 Blockade.ADVANCED MATERIALS,16. |
| MLA | Yi, Wenzhe,et al."A Dendritic Cell-Nanogel Conjugate for Tumor-Draining Lymph Node-Specific PD-L1 Blockade".ADVANCED MATERIALS (2025):16. |
入库方式： OAI收割
来源：上海药物研究所
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