Lycium barbarum Polysaccharide Ameliorates Hindlimb Unloading-Induced Bone Loss by Targeting Noggin
文献类型：期刊论文
| 作者 | Sun, Chuanxin1; He, Yuke1,2; Chen, Xia3; Ding, Kan2,3,4; Chen, Chang1,2,5 |
| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2025-07-15 |
| 卷号 | 39期号:13页码:14 |
| 关键词 | BMP signaling
disuse bone loss
|
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.202403082R |
| 英文摘要 | Disuse bone loss is a common metabolic bone disease with limited effective, safe treatments. Lycium barbarum (L. barbarum), a traditional Chinese medicine and popular health food, has been historically noted in Ben Cao Gang Mu (Compendium of Materia Medica) for its bone-strengthening properties. However, the effects of L. barbarum on disuse bone loss and the underlying mechanisms remain unclear. This study used a hindlimb-unloading mouse model and a simulated microgravity model of MC3T3-E1 cells in a rotary cell culture system to investigate the role of L. barbarum water extract (LBE) and polysaccharide (LBP). LBE and LBP significantly enhanced bone mass and strength in hindlimb-unloaded mice. Further analysis identified a polysaccharide component, LBPP, as the active ingredient mediating these effects. LBPP enhanced osteoblast differentiation and ossification under normal conditions and promoted osteoblast activity under simulated microgravity. Mechanistic studies revealed that LBPP directly binds to noggin, a potent inhibitor of BMPs, facilitating phosphorylation of downstream Smads to stimulate bone formation. These findings demonstrate the potential of L. barbarum as a functional food for preventing disuse bone loss and provide a theoretical basis for its therapeutic applications. |
| WOS关键词 | MUSCLE ATROPHY ; MINERAL LOSS ; BED REST ; BISPHOSPHONATES ; EXERCISE |
| 资助项目 | Beijing Natural Science Foundation |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001525027000001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321060]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Ding, Kan; Chen, Chang |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Key Lab Biomacromol CAS,Natl Lab Biomacromol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, SSIP Healthcare & Med Demonstrat Zone, Zhongshan, Guangdong, Peoples R China 5.Capital Med Univ, Beijing Inst Brain Disorders, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Chuanxin,He, Yuke,Chen, Xia,et al. Lycium barbarum Polysaccharide Ameliorates Hindlimb Unloading-Induced Bone Loss by Targeting Noggin[J]. FASEB JOURNAL,2025,39(13):14. |
| APA | Sun, Chuanxin,He, Yuke,Chen, Xia,Ding, Kan,&Chen, Chang.(2025).Lycium barbarum Polysaccharide Ameliorates Hindlimb Unloading-Induced Bone Loss by Targeting Noggin.FASEB JOURNAL,39(13),14. |
| MLA | Sun, Chuanxin,et al."Lycium barbarum Polysaccharide Ameliorates Hindlimb Unloading-Induced Bone Loss by Targeting Noggin".FASEB JOURNAL 39.13(2025):14. |
入库方式： OAI收割
来源：上海药物研究所
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