Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema
文献类型：期刊论文
| 作者 | Wang, Zhiyi1,3; Zhang, Shijie3,4; Irakoze, Loica Melita3,4; Zhao, Yujun2,3,4 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2025-11-05 |
| 卷号 | 297页码:20 |
| 关键词 | p53 MDM2 Protein-protein interaction Mutant p53 Gene therapy PROTAC Degrader |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2025.117909 |
| 英文摘要 | p53, encoded by the TP53 gene, is a critical tumor suppressor, and its pharmacological activation has been clinically validated as an effective strategy for the treatment of human malignancies. In recent years, numerous novel approaches have emerged to activate both wild-type and mutant p53, including MDM2 degraders, p53 stabilizers, gene therapies targeting TP53, and inhibitors of the MDM2-p53 protein-protein interaction. Since 2020, drug discovery efforts in these areas have advanced rapidly, leading to several notable breakthroughs. This review provides a comprehensive overview of recently reported agents that enhance p53 function, with particular emphasis on those that have progressed to clinical trials or are capable of restoring p53 activity in cancers harboring TP53 mutations. We aim to offer an up-to-date snapshot of the evolving landscape of p53targeted therapies and to serve as a reference for future drug discovery endeavors in this important field. |
| WOS关键词 | PROTEIN-PROTEIN INTERACTION ; MOLECULE MDM2 INHIBITOR ; WILD-TYPE P53 ; HIGHLY POTENT ; SOLID TUMORS ; STRUCTURAL BASIS ; CLINICAL-TRIALS ; IN-VITRO ; AMG 232 ; DISCOVERY |
| 资助项目 | National Natural Science Foundation of China[82273759] ; National Natural Science Foundation of China[82073682] ; State Key Laboratory of Drug Research at Shanghai Institute of Materia Medica[SIMM0320231008] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001525272500006 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321063]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Zhao, Yujun |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 2.Ningxia Med Univ, Sch Pharm, Key Lab Protect Dev & Utilizat Med Resources Liupa, Minist Educ, 1160 Shengli St, Yinchuan 750004, Ningxia, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhiyi,Zhang, Shijie,Irakoze, Loica Melita,et al. Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2025,297:20. |
| APA | Wang, Zhiyi,Zhang, Shijie,Irakoze, Loica Melita,&Zhao, Yujun.(2025).Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,297,20. |
| MLA | Wang, Zhiyi,et al."Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 297(2025):20. |
入库方式： OAI收割
来源：上海药物研究所
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