Indole diketopiperazine alkaloids from a soil-derived fungus Aspergillus sp. KYS-11
文献类型：期刊论文
| 作者 | Liu, Jing1,2; Gao, Wen-Jing2; Fang, Chu-Hong2; Li, Ying2; Liu, Xiang-Yu2; Lv, Ming-Jun2; Yue, Jian-Min2,3; Yu, Jin-Hai1,2 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2025-09-01 |
| 卷号 | 185页码:9 |
| 关键词 | Fungus Aspergillus sp. IDAs Inversed C-18 configuration Immunosuppressive |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2025.106697 |
| 英文摘要 | Seven new indole diketopiperazine alkaloids (IDAs) asperdiketopoids A-G (1-7) and nine known analogues (8-16) were isolated from a Kunyu Mountain soil-derived fungus Aspergillus sp. KYS-11. Asperdiketopoid C (3) is characterized by the oxidation at C-12, a feature that is infrequently documented in the family of IDAs. Asperdiketopoids F (6) and G (7) feature an inversed C-18 configuration in the spirocyclic IDA family, marking the first time such a feature has been reported as natural products. One should be cautious that the C-18 epimers possess a nearly identical set of NMR data, making it susceptible to misidentification in the structure elucidations. A series of bioactive evaluations demonstrated that asperdiketopoids C (3) and G (7) display a certain degree of inhibition against the proliferation of B cells induced by LPS. |
| WOS关键词 | CELL CYCLE INHIBITORS ; 11-BETA-HSD1 INHIBITORS ; SPIROTRYPROSTATIN-B ; ENDOPHYTIC FUNGUS ; FUMIGATUS ; TRITERPENOIDS ; IDENTIFICATION ; METABOLITES ; LIMONOIDS |
| 资助项目 | Key R&D Program of Shandong Province, China[2024CXPT029] ; Shandong Laboratory Program[SYS202205] ; Natural Science Foundation of Shandong Province[ZR2024QB356] ; Shandong Postdoctoral Science Foundation[SDCX-ZG-202400081] ; Shanghai Postdoctoral Excellence Program[2023701] ; National Natural Science Foundation of China[22237007] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001522226000002 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321075]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Yue, Jian-Min; Yu, Jin-Hai |
| 作者单位 | 1.Shandong First Med Univ & Shandong Acad Med Sci, Jinan 250117, Shandong, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jing,Gao, Wen-Jing,Fang, Chu-Hong,et al. Indole diketopiperazine alkaloids from a soil-derived fungus Aspergillus sp. KYS-11[J]. FITOTERAPIA,2025,185:9. |
| APA | Liu, Jing.,Gao, Wen-Jing.,Fang, Chu-Hong.,Li, Ying.,Liu, Xiang-Yu.,...&Yu, Jin-Hai.(2025).Indole diketopiperazine alkaloids from a soil-derived fungus Aspergillus sp. KYS-11.FITOTERAPIA,185,9. |
| MLA | Liu, Jing,et al."Indole diketopiperazine alkaloids from a soil-derived fungus Aspergillus sp. KYS-11".FITOTERAPIA 185(2025):9. |
入库方式： OAI收割
来源：上海药物研究所
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