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Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy

文献类型：期刊论文

作者Chen, Fangmin1,2,3; Zhang, Huijuan1,2; Li, Shiqin1,2; Ren, Siyuan1,2,4; Huang, Lujia1,2,3; Cai, Zhixiong5; Yin, Lichen6; Zheng, Mingyue7; Liu, Xiaolong5; Xu, Zhiai8
刊名NATURE COMMUNICATIONS
出版日期2025-07-01
卷号16期号:1页码:21
DOI10.1038/s41467-025-60927-7
英文摘要Spatiotemporally-tailored activation of dendritic cells (DC) in lymph nodes (LN) remains a critical challenge for effective cancer vaccination therapy. In this study, we show that photo/sonodynamic effect can trigger the nuclear transcription factor-kappa B (NF-kappa B) and stimulator of interferon genes (STING) pathways activation in DC. We engineers a library of spatiotemporally-tailored STING nanoadjuvants (SNA) by conjugating the photo/sonosensitizer and STING agonist onto the biodegradable polypeptide, and co-assembling with charge-modified polypeptides. The combination of antigen-loaded SNA vaccine (SNVac) with laser irradiation or ultrasound stimulation (namely SNVac-L or SNVac-US) efficiently facilitates DC activation and induces antigen-specific CD8+ T cell response in vivo comparing to the free mixture of antigen with STING agonist. We further demonstrate that SNVac-L monotherapy or combination therapy with immune checkpoint blockade (ICB) elicits antitumor immunity to reduce tumor size and prevent tumor relapse in multiple mouse tumor models. This study thus provides a potential translational strategy for spatiotemporally-tailored innate immunity stimulation of DC to potentiate cancer immunotherapy.
WOS关键词VACCINES ; STRESS ; DNA
资助项目National Natural Science Foundation of China (National Science Foundation of China)[U22A20328] ; National Natural Science Foundation of China (National Science Foundation of China)[W2412035] ; National Natural Science Foundation of China (National Science Foundation of China)[22474042] ; National Natural Science Foundation of China[23490712700] ; National Natural Science Foundation of China[24430713500] ; National Natural Science Foundation of China[23ZR1475000] ; Science and Technology Commission of Shanghai Municipality[BJKL2024046] ; Shanghai Oriental Talents Program[SKLDR-2023-KF-09] ; Open Funds of State Key Laboratory of Drug Research ; National Facility for Protein Science in Shanghai (NFPS), Shanghai Advanced Research Institute, CAS ; Shanghai Institute of Materia Medica, CAS
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001523460000030
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/321078]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Xu, Zhiai; Yu, Haijun
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
5.Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China
6.Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
8.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China
9.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Fangmin,Zhang, Huijuan,Li, Shiqin,et al. Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy[J]. NATURE COMMUNICATIONS,2025,16(1):21.
APA Chen, Fangmin.,Zhang, Huijuan.,Li, Shiqin.,Ren, Siyuan.,Huang, Lujia.,...&Yu, Haijun.(2025).Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy.NATURE COMMUNICATIONS,16(1),21.
MLA Chen, Fangmin,et al."Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy".NATURE COMMUNICATIONS 16.1(2025):21.

入库方式： OAI收割

来源：上海药物研究所

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