中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 国家级研究中心
  5. 原创新药研究全国重点实验室
Biomimetically engineered plant-derived exosomes-like nanovesicles for rheumatoid arthritis therapy

文献类型：期刊论文

作者Zhang, Yangyang1,2; Qiu, Lu1,2; Li, Houying1,2; Cai, Wenli1,2; Liu, Ergang2; Zhang, Hongtao3; Muhitdinov, Bahtiyor4; Liang, Jianming1; Huang, Yongzhuo1,2,5,6
刊名CHINESE CHEMICAL LETTERS
出版日期2025-09-01
卷号36期号:9页码:6
关键词Rheumatoid arthritis Morinda officinalis How. Plant-derived exosome like-nanovesicles UV irradiation Erythrocyte membrane coating Targeted delivery
ISSN号1001-8417
DOI10.1016/j.cclet.2024.110658
英文摘要Rheumatoid arthritis (RA) is a refractory autoimmune disease with limited treatment options. Plantderived exosomes-like nanovesicles (PDENs) have emerged as a novel nanomedical approach, with the inherent bioactive compounds from their source plants. The roots of Morinda officinalis How. (MO), a Chinese herb, exhibit notable anti-inflammatory activities and hold promising therapeutic value. We engineered a joint-targeting delivery system (termed MOE@EM) by masking MO-derived exosomes-like nanovesicles (MOE) with erythrocyte membrane (EM). This biomimetic strategy, using EM camouflage, is intended to improve the in vivo fate of MOE. We investigated the antioxidative and anti-inflammatory activities, immunogenicity, drug accumulation in the joint, and therapeutic efficacy to ascertain its suitability for RA therapy. UV irradiation significantly increased the activities of catalase and peroxidase of MOE, and enhanced the anti-inflammatory effects via the Wnt/ beta-catenin pathway. Furthermore, MOE@EM markedly attenuated dendritic cell activation. MOE@EM exhibited joint-specific delivery, with substantial reduction in paw swelling, and favorable modulation of immune microenvironment. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
WOS关键词BLOOD-CELL MEMBRANE ; MACROPHAGES
资助项目National Key Research and Development Program of China[2021YFC240 060 0] ; National Key Research and Development Program of China[2022YFE0203600] ; National Natural Science Foundation of China[81925035] ; National Natural Science Foundation of China[82304842] ; National Natural Science Foundation of China[82204628] ; High-level Innovative Research Institute[2021B0909050 0 03] ; Chinese Academy of Sciences President's International Fellowship Initiative[2024VBB0 0 04] ; Scientific and Technological Innovation Projects in Zhongshan City[LJ2021001] ; Scientific and Technological Innovation Projects in Zhongshan City[CXTD2022011] ; Social Welfare and Basic Research Projects in Zhongshan[221014134359625] ; Special Projects in Key Areas of Colleges and Universities in Guangdong Province[2022ZDZX2015] ; Science and Technology Program of Guangzhou[2024A04J4899] ; Young Talent Project of Guangzhou Uni-versity of Chinese Medicine[24-414-110Z76]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001533731400009
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/321087]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Liu, Ergang; Liang, Jianming; Huang, Yongzhuo
作者单位1.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, Guangzhou 510450, Peoples R China
2.Zhongshan Inst Drug Discovery, SIMM, CAS, Zhongshan 528437, Peoples R China
3.Zhongshan Torch Dev Zone Peoples Hosp, Dept Orthoped, Zhongshan 528400, Peoples R China
4.Uzbek Acad Sci, Inst Bioorgan Chem, Tashkent 100125, Uzbekistan
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
6.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yangyang,Qiu, Lu,Li, Houying,et al. Biomimetically engineered plant-derived exosomes-like nanovesicles for rheumatoid arthritis therapy[J]. CHINESE CHEMICAL LETTERS,2025,36(9):6.
APA Zhang, Yangyang.,Qiu, Lu.,Li, Houying.,Cai, Wenli.,Liu, Ergang.,...&Huang, Yongzhuo.(2025).Biomimetically engineered plant-derived exosomes-like nanovesicles for rheumatoid arthritis therapy.CHINESE CHEMICAL LETTERS,36(9),6.
MLA Zhang, Yangyang,et al."Biomimetically engineered plant-derived exosomes-like nanovesicles for rheumatoid arthritis therapy".CHINESE CHEMICAL LETTERS 36.9(2025):6.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。