Viroporins beyond pathogenesis: Ion channel properties as the key to unlocking a neglected antiviral target
文献类型：期刊论文
| 作者 | Peng, Suya1,2; Wang, Yi1,2; Gao, Zhaobing1,2; Xia, Bingqing1,2 |
| 刊名 | PHARMACOLOGICAL RESEARCH
 |
| 出版日期 | 2025-09-01 |
| 卷号 | 219页码:14 |
| 关键词 | Viroporins Ion selectivity Pathogenic mechanism Anti-viral drug discovery |
| ISSN号 | 1043-6618 |
| DOI | 10.1016/j.phrs.2025.107863 |
| 英文摘要 | A class of proteins encoded by viral genomes, referred to as viroporins, is composed of small hydrophobic proteins that form pores or ion channels in host membranes. These proteins modulate the viral life cycle and pathogenicity. Despite their early discovery and functional significance, viroporins have long remained underexploited as antiviral drug targets-partly due to the emergence of alternative antiviral strategies, viral evolutionary complexity, and technical limitations in studying channel function. Nonetheless, accumulating evidence underscores their essential roles in pathogenesis and viral fitness, positioning them as promising but underdeveloped therapeutic targets. While recent reviews have revisited the field, most have focused on the pathological functions of viroporins, with little attention given to the fundamental biophysical properties that define them as ion channels. Given that channel function is intrinsically governed by attributes such as ion selectivity and gating mechanisms, a mechanistic understanding of these properties is critical for understanding the pathogenic mechanism and rational drug development. To our knowledge, no prior review has systematically addressed viroporins from a channel-centric perspective. Here, we propose a reclassification framework grounded in the core biophysical attributes of viral channels, highlighting their ion permeability, gating behavior, and regulatory features. By shifting the focus from pathophysiology to channel function, this work aims to provide a conceptual foundation for future antiviral strategies and to stimulate broader interest in this underexplored but compelling class of viral targets. |
| WOS关键词 | HEPATITIS-C-VIRUS ; SMALL HYDROPHOBIC PROTEIN ; VIRAL-PROTEINS ; PROTON CHANNEL ; VPU PROTEIN ; 6K PROTEIN ; P7 ; MECHANISM ; FORMS ; SELECTIVITY |
| 资助项目 | National Natural Science Foundation of China[92169202] ; National Natural Science Foundation of China[82341058] ; National Natural Science Foundation of China[82202491] ; National Natural Science Foundation of China[82394463] ; Chinese Academy of Sciences[PTYQ2024YZ0008] ; Shanghai Municipal Science and Technology Major Project[23JC1404301] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001540626100001 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321156]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Gao, Zhaobing; Xia, Bingqing |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Suya,Wang, Yi,Gao, Zhaobing,et al. Viroporins beyond pathogenesis: Ion channel properties as the key to unlocking a neglected antiviral target[J]. PHARMACOLOGICAL RESEARCH,2025,219:14. |
| APA | Peng, Suya,Wang, Yi,Gao, Zhaobing,&Xia, Bingqing.(2025).Viroporins beyond pathogenesis: Ion channel properties as the key to unlocking a neglected antiviral target.PHARMACOLOGICAL RESEARCH,219,14. |
| MLA | Peng, Suya,et al."Viroporins beyond pathogenesis: Ion channel properties as the key to unlocking a neglected antiviral target".PHARMACOLOGICAL RESEARCH 219(2025):14. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。