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Advancements and future perspectives of triphenylamine-based fluorescent probes in biomedical applications

文献类型：期刊论文

作者Ding, Qihang1,2; Li, Yaoqiang3; Zhang, Nan3; Wang, Bo1; Qian, Kun4; Wang, Qingzhi3; Xiang, Chunbai5; Wang, Yue5; Ma, Gongcheng3; Gong, Ping5
刊名ACTA BIOMATERIALIA
出版日期2025-08-01
卷号202页码:104-126
关键词Fluorescent probe Molecular imaging Triphenylamine Phototherapy Aggregation-induced emission
ISSN号1742-7061
DOI10.1016/j.actbio.2025.07.024
英文摘要Triphenylamine (TPA)-based fluorescent probes and advanced materials have garnered significant attention in biomedical research owing to their distinctive optoelectronic properties and versatile donor-acceptor (D-A) structural configurations. These materials exhibit excellent photophysical and photochemical behaviors, making them ideal for molecular imaging, disease diagnosis, and therapeutic applications, particularly in phototherapy. TPA derivatives have been engineered to enhance environment-responsive fluorescence, signal-to-noise ratios, and tissue penetration, significantly advancing their theranostic potential. The integration of TPA-based systems with advanced molecular design strategies, such as twisted intramolecular charge transfer (TICT), intramolecular charge transfer (ICT), and Forster resonance energy transfer (FRET), has further improved probe selectivity and sensitivity, enabling precise bioimaging and targeted therapy. This review provides a comprehensive overview of recent developments in TPA-based materials, discussing their structural design, underlying mechanisms, biomedical applications, and future prospects for clinical translation. Statement of significance: Triphenylamine (TPA)-based fluorescent probes and functional materials have emerged as a pivotal class of optoelectronic platforms with significant implications for biomedical imaging, diagnostics, and therapy. Their distinctive donor-acceptor (D-A) structures, coupled with tunable photophysical properties, enable high-contrast fluorescence imaging and efficient light-driven therapeutic interventions, such as photodynamic and photothermal therapy. Recent advancements in molecular design strategies, including aggregationinduced emission (AIE), twisted intramolecular charge transfer (TICT), and Forster resonance energy transfer (FRET), have further enhanced their selectivity, sensitivity, and tissue penetration capabilities, overcoming key limitations of conventional fluorophores. The integration of TPA derivatives into nanostructured platforms has also expanded their applicability, improving biocompatibility and theranostic precision. This review provides a comprehensive analysis of the structural innovations, mechanistic insights, and translational potential of TPAbased materials, offering critical perspectives for their future deployment in biomedical research and clinical applications.
WOS关键词CANCER ; THERAPY
资助项目National Key Research and Development Program of China[2021YFA0910000] ; China Scholarship Council (CSC)[202106270027] ; National Natural Science Foundation of China[22474152] ; National Natural Science Foundation of China[22271222] ; National Natural Science Foundation of China[21871214] ; National Natural Science Foundation of China[U2267221] ; Guangdong Provincial Natural Science Foundation[2024A1515010635] ; Shenzhen Science and Technology Program[JCYJ20220818101607016] ; Gansu Science and Technology Major Project[23ZDFA014] ; State Key Laboratory of Drug Research[SIMM0120231004] ; Shandong Laboratory Program[SYS202205] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB0830300]
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:001544066000002
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/321159]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Ma, Gongcheng; Gong, Ping; Cheng, Zhen; Tian, Jian
作者单位1.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Cardiovasc Surg, Wuhan 430071, Peoples R China
2.Korea Univ, Dept Chem, Seoul 02841, South Korea
3.Xinxiang Med Univ, Sch Life Sci & Technol, Xinxiang 453003, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, CAS Key Lab Biomed Imaging Sci & Syst,State Key La, Shenzhen Inst Adv Technol,Key Lab Biomed Imaging, Guangdong Key Lab Nanomed,CAS HK Joint Lab Biomat, Shenzhen 518055, Peoples R China
推荐引用方式
GB/T 7714		 Ding, Qihang,Li, Yaoqiang,Zhang, Nan,et al. Advancements and future perspectives of triphenylamine-based fluorescent probes in biomedical applications[J]. ACTA BIOMATERIALIA,2025,202:104-126.
APA Ding, Qihang.,Li, Yaoqiang.,Zhang, Nan.,Wang, Bo.,Qian, Kun.,...&Tian, Jian.(2025).Advancements and future perspectives of triphenylamine-based fluorescent probes in biomedical applications.ACTA BIOMATERIALIA,202,104-126.
MLA Ding, Qihang,et al."Advancements and future perspectives of triphenylamine-based fluorescent probes in biomedical applications".ACTA BIOMATERIALIA 202(2025):104-126.

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来源：上海药物研究所

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