Lipid nanoparticle-mediated targeted mRNA delivery and its application in cancer therapy
文献类型：期刊论文
| 作者 | Sui, Yuan1; Hou, Xiaowen2,3,4; Zhang, Juan3,6; Hong, Xuechuan2,3,4,5; Wang, Hongbo1; Xiao, Yuling2,3,5,6; Zeng, Xiaodong2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2025-08-20 |
| 卷号 | 13期号:33页码:10085-10117 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/d5tb01556a |
| 英文摘要 | mRNA technology has gained significant attention due to its successful application in COVID-19 vaccines, becoming a vital research area in disease treatment. Achieving therapeutic efficacy requires mRNA to efficiently enter target cells and express functional proteins, highlighting the urgent need for effective delivery systems. Lipid nanoparticles (LNPs) have emerged as a crucial enabler for the clinical translation of mRNA therapies, thanks to their remarkable delivery capabilities. Several mRNA-based therapies have now been approved or are in clinical trials, underscoring the vast potential of mRNA technology. This review provides a comprehensive overview of the application of mRNA-LNP in cancer therapy. It systematically summarizes strategies for optimizing LNP composition, introduces innovative synthesis methods and AI-driven formula optimization, and explores targeted delivery strategies. Additionally, it delves into the various applications of mRNA in cancer treatment, including mRNA tumor vaccines, adoptive cell transfer therapies, restoration of tumor suppressors, immunomodulatory factors, combination therapies, and other emerging treatments. By addressing current challenges and future directions, this review aims to offer valuable insights for further research in this field. |
| WOS关键词 | CAR T-CELLS ; IN-VIVO ; HEMATOPOIETIC STEM ; IONIZABLE LIPIDS ; OPTIMIZATION ; EXPRESSION ; DESIGN |
| 资助项目 | Taishan Scholar Project of Shandong Province[2023YFC3605500] ; National Key R&D Program of China[22477129] ; National Key R&D Program of China[82273796] ; National Key R&D Program of China[82372005] ; National Key R&D Program of China[82171986] ; National Natural Science Foundation of China[TSQN202306320] ; Taishan Scholar Project of Shandong Province[ZR2023MB085] ; Taishan Scholar Project of Shandong Province[ZR2024QH253] ; Natural Science Foundation of Shandong Province[SYS202205] ; Shandong Laboratory Program |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001542680400001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321165]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Wang, Hongbo; Xiao, Yuling; Zeng, Xiaodong |
| 作者单位 | 1.Yantai Univ, Univ Shandong, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat,Min, Yantai 264005, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery Yantai, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Wuhan Univ, Clin Trial Ctr,Zhongnan Hosp, Sch Pharmaceut Sci, Dept Radiol, Wuhan 430071, Peoples R China 5.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sui, Yuan,Hou, Xiaowen,Zhang, Juan,et al. Lipid nanoparticle-mediated targeted mRNA delivery and its application in cancer therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2025,13(33):10085-10117. |
| APA | Sui, Yuan.,Hou, Xiaowen.,Zhang, Juan.,Hong, Xuechuan.,Wang, Hongbo.,...&Zeng, Xiaodong.(2025).Lipid nanoparticle-mediated targeted mRNA delivery and its application in cancer therapy.JOURNAL OF MATERIALS CHEMISTRY B,13(33),10085-10117. |
| MLA | Sui, Yuan,et al."Lipid nanoparticle-mediated targeted mRNA delivery and its application in cancer therapy".JOURNAL OF MATERIALS CHEMISTRY B 13.33(2025):10085-10117. |
入库方式： OAI收割
来源：上海药物研究所
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