Endoplasmic reticulum-targeted strategies for programmed cell death in cancer therapy: Approaches and prospects
文献类型：期刊论文
| 作者 | Liang, Li1,2; Zhu, Zhu1; Jiang, Xiaohe1,3; Tang, Yan1,2; Li, Jiaxin1,3; Zhang, Zilong1; Ding, Bingwen1,3; Li, Xiang1,3; Yu, Miaorong1,2,3; Gan, Yong1,2,3,4 |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2025-09-10 |
| 卷号 | 385页码:17 |
| 关键词 | Endoplasmic reticulum Targeted drug delivery Nanoparticle Programmed cell death Anti-cancer therapy |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2025.114059 |
| 英文摘要 | The endoplasmic reticulum (ER) plays a dual role in cancer biology, functioning both to preserve cellular homeostasis and to facilitate pathological progression. Rapidly proliferating cancer cells, which exhibit heightened metabolic activity, frequently experience ER stress that activates the unfolded protein response (UPR), a mechanism that promotes cellular adaptation and survival. However, when ER stress is prolonged or excessive, it can shift the balance toward programmed cell death (PCD), including apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis. Given the ER's central role in regulating proteostasis and stress signaling, therapeutically targeting the ER presents a compelling strategy to disrupt cancer cell survival and overcome treatment resistance. Nanomedicine, particularly the use of nanoparticles (NPs) for precise ER targeting, offers a promising platform to modulate ER function and trigger PCD in cancer cells. In this review, we highlight recent advances in the design guidelines of ER-targeted NPs, with a focus on their capacity to engage and activate PCD pathways in cancer cells. We further discuss the current limitations and emerging opportunities in this field, aiming to inform the development of next-generation ER-targeted delivery platforms for enhanced efficacy in cancer treatment. |
| WOS关键词 | ER STRESS ; PYROPTOSIS ; NANOPARTICLES ; FERROPTOSIS ; APOPTOSIS ; AUTOPHAGY ; DELIVERY ; NECROPTOSIS ; MECHANISMS ; PEPTIDE |
| 资助项目 | National Science Fund of Distin-guished Young Scholars[82025032] ; National Key Research and Development Program of China[2024YFA1210100] ; National Natural Science Foundation of China[82430111] ; Shanghai Action Plan for Science, Technology and Innovation[23HC1401200] ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM0220232001] ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences[NCTIB2022HS01006] ; Key Research Program of Chinese Academy of Sciences[ZDBS-ZRKJZ-TLC005] ; Natural Science Foundation of Shanghai[25ZR1401382] ; SANOFI Scholarship Program ; Open fund of State Key Laboratory of Advanced Drug Formulations[2025-KFA-005] ; TCM Elite Innovative Talent Research Funding Program[CXZ2025008] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001543999700001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321168]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Yu, Miaorong; Gan, Yong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Li,Zhu, Zhu,Jiang, Xiaohe,et al. Endoplasmic reticulum-targeted strategies for programmed cell death in cancer therapy: Approaches and prospects[J]. JOURNAL OF CONTROLLED RELEASE,2025,385:17. |
| APA | Liang, Li.,Zhu, Zhu.,Jiang, Xiaohe.,Tang, Yan.,Li, Jiaxin.,...&Gan, Yong.(2025).Endoplasmic reticulum-targeted strategies for programmed cell death in cancer therapy: Approaches and prospects.JOURNAL OF CONTROLLED RELEASE,385,17. |
| MLA | Liang, Li,et al."Endoplasmic reticulum-targeted strategies for programmed cell death in cancer therapy: Approaches and prospects".JOURNAL OF CONTROLLED RELEASE 385(2025):17. |
入库方式： OAI收割
来源：上海药物研究所
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