Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC Channels
文献类型：期刊论文
| 作者 | Qiao, Xue1,2,3,4; Ren, Chunlin1,2,3,5,6; Wang, Wumei4,6; Wang, Xiaofen1,2,3,4; Li, Guo-Bo7,8; Chen, Cheng9; Ye, Bengui7,8,10; Zeng, Xiaodong1,2,3; Xiao, Yuling1,2,3,6; Hong, Xuechuan1,2,3,4,5 |
| 刊名 | MEDICINAL RESEARCH REVIEWS
 |
| 出版日期 | 2025-07-30 |
| 页码 | 37 |
| 关键词 | cryo-electron microscopy structure modulators physiological TRP TRPC |
| ISSN号 | 0198-6325 |
| DOI | 10.1002/med.70007 |
| 英文摘要 | Transient receptor potential canonical (TRPC) channels, a subfamily of calcium-permeable cation channels, regulate diverse physiological processes and are implicated in disorders including neurological conditions, cardiovascular diseases, and chronic kidney disease. Recent advances in cryo-electron microscopy (cryo-EM) have elucidated TRPC structures, while subtype-selective modulators have clarified their pathophysiological roles and therapeutic potential. This review integrates the structural and functional attributes of TRPC channels, emphasizing their contributions to health and disease. We highlight synthetic strategies and structure-activity relationships driving the development of selective pharmacological tools, several of which show preclinical promise. By uniting TRPC biology with medicinal chemistry, this study provides strategic guidance for advancing clinically viable TRPC-targeted therapeutics. |
| WOS关键词 | RECEPTOR POTENTIAL CHANNELS ; OPERATED CA2+ ENTRY ; PULMONARY-HYPERTENSION ; DYNAMIC INTERACTION ; KIDNEY-DISEASE ; BREAST-CANCER ; UP-REGULATION ; INHIBITOR ; CELLS ; PYR3 |
| 资助项目 | National Key R&D Program of China[2023YFC3605500] ; National Natural Science Foundation of China[22477129] ; National Natural Science Foundation of China[82273796] ; Shenzhen Science and Technology Research Grant[JCYJ20240813111300001] ; Shenzhen Science and Technology Research Grant[JCYJ20220530140605012] ; Shenzhen Science and Technology Research Grant[JCYJ20230807090100002] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515012649] ; Taishan Scholar Project of Shandong Province[TSQN202306320] ; Shandong Provincial Natural Science Foundation[ZR2024QH253] ; Tibet Autonomous Region Science and Technology Plan Project Key Project[XZ202301ZY0014G] ; Tibet Autonomous Region Science and Technology Plan Project Key Project[LSKJ202445] ; Natural Science Foundation of Shandong Province[ZR2023MB085] ; Shandong Laboratory Program[SYS202205] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001540251600001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321180]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Chen, Cheng; Ye, Bengui; Zeng, Xiaodong; Xiao, Yuling; Hong, Xuechuan |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery Yantai, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai, Peoples R China 4.Wuhan Univ, Zhongnan Hosp, Clin Trial Ctr, Sch Pharmaceut Sci,Dept Radiol, Wuhan, Peoples R China 5.Fudan Univ, Sch Pharm, Shanghai, Peoples R China 6.Wuhan Univ, Shenzhen Inst, Shenzhen, Peoples R China 7.Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug,Minist Educ, Chengdu, Peoples R China 8.Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu, Peoples R China 9.Wuhan Univ, Renmin Hosp, Div Nephrol, Wuhan, Peoples R China 10.Tibet Univ, Med Coll, Lasa, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiao, Xue,Ren, Chunlin,Wang, Wumei,et al. Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC Channels[J]. MEDICINAL RESEARCH REVIEWS,2025:37. |
| APA | Qiao, Xue.,Ren, Chunlin.,Wang, Wumei.,Wang, Xiaofen.,Li, Guo-Bo.,...&Hong, Xuechuan.(2025).Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC Channels.MEDICINAL RESEARCH REVIEWS,37. |
| MLA | Qiao, Xue,et al."Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC Channels".MEDICINAL RESEARCH REVIEWS (2025):37. |
入库方式： OAI收割
来源：上海药物研究所
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