Stem cell-derived exosomes in complicated urinary tract infections: immunomodulatory mechanisms and potential therapeutic strategies for urothelial repair
文献类型：期刊论文
| 作者 | Wang, Wenjing1; He, Yong4; Zhang, Henghui2,3; Wang, Yan1 |
| 刊名 | STEM CELL RESEARCH & THERAPY
 |
| 出版日期 | 2025-08-05 |
| 卷号 | 16期号:1页码:13 |
| 关键词 | Complicated urinary tract infection Stem cell-derived exosomes Immunomodulation Urothelial repair Antimicrobial resistance |
| DOI | 10.1186/s13287-025-04548-3 |
| 英文摘要 | Complicated urinary tract infection (cUTI), characterized by recurrent episodes due to multidrug-resistant bacterial infections and biofilm formation, severely compromises patients' quality of life. Although uropathogenic Escherichia coli remains the primary pathogen, its ability to form biofilms and induce persistent inflammatory responses exacerbates urothelial damage, thereby aggravating the disease. Current antibiotic treatments face resistance issues and inability to promote tissue repair, emphasizing the need for innovative treatments. Stem cell-derived exosomes have emerged as a promising solution for cUTI treatment due to their unique anti-inflammatory and tissue-repairing properties. In addition, advancements in targeted drug delivery and biomaterial integration have increased drug stability and therapeutic precision. These innovations have the potential to revolutionize the treatment of multidrug-resistant bacterial infections and the repair of complicated tissue damage, offering improved patient outcomes and addressing the limitations of traditional therapies. |
| WOS关键词 | EXPERIMENTAL COLITIS ; HYDROGEL ; TOLERANCE ; DELIVERY ; RELEASE ; DRIVEN ; INJURY ; EXO |
| WOS研究方向 | Cell Biology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:001545554700002 |
| 出版者 | BMC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321198]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Wang, Yan |
| 作者单位 | 1.Peking Univ First Hosp, Dept Infect Dis, Beijing 100034, Peoples R China 2.Capital Med Univ, Beijing Shijitan Hosp, Biomed Innovat Ctr, Beijing 100038, Peoples R China 3.Capital Med Univ, Beijing Shijitan Hosp, Beijing Key Lab Therapeut Canc Vaccines, Beijing 100038, Peoples R China 4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med SIMM, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wenjing,He, Yong,Zhang, Henghui,et al. Stem cell-derived exosomes in complicated urinary tract infections: immunomodulatory mechanisms and potential therapeutic strategies for urothelial repair[J]. STEM CELL RESEARCH & THERAPY,2025,16(1):13. |
| APA | Wang, Wenjing,He, Yong,Zhang, Henghui,&Wang, Yan.(2025).Stem cell-derived exosomes in complicated urinary tract infections: immunomodulatory mechanisms and potential therapeutic strategies for urothelial repair.STEM CELL RESEARCH & THERAPY,16(1),13. |
| MLA | Wang, Wenjing,et al."Stem cell-derived exosomes in complicated urinary tract infections: immunomodulatory mechanisms and potential therapeutic strategies for urothelial repair".STEM CELL RESEARCH & THERAPY 16.1(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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