A Viscosity-Responsive Mitochondria-Targeting Ir(III) Probe for Inducing and Monitoring Photodynamic-Triggered Ferroptosis
文献类型：期刊论文
| 作者 | Xu, Ruitong1; Sun, Kangjun2; Li, Yaoqiang3; Zhang, Nan3; Liu, Bi4; Ye, Mujie5; Pan, Jialing1; Qian, Kun6; Ding, Qihang7; Tang, Qiyun5 |
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2025-08-28 |
| 卷号 | 68期号:16页码:17667-17677 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.5c01377 |
| 英文摘要 | Colorectal cancer (CRC) is a major cause of cancer-related death, with poor outcomes at advanced stages due to metastasis and limited early detection. Photodynamic therapy (PDT), which relies on reactive oxygen species (ROS) to kill tumor cells, is promising but limited by hypoxia and short ROS diffusion distances. Here, we report Ir-EA, a novel cyclometalated Ir(III) complex with enhanced mitochondrial targeting and dual ROS generation capability, effective under both oxygen-rich and hypoxic conditions. Ir-EA induces ferroptosis, a form of oxidative stress-related cell death, offering a strategy to overcome drug resistance. Additionally, Ir-EA exhibits viscosity-sensitive fluorescence, enabling real-time monitoring of mitochondrial microviscosity changes during ferroptosis. This dual functionality-therapeutic induction and diagnostic imaging-enhances the efficacy of PDT and provides a noninvasive means to assess therapeutic responses. Overall, Ir-EA represents a promising platform for improving cancer treatment and advancing theranostic applications. |
| WOS关键词 | CANCER ; ROLES ; ROS |
| 资助项目 | National Natural Science Foundation of China[PY202431] ; Young Scholars Fostering Fund of the First Affiliated Hospital of Nanjing Medical University[22005343] ; Young Scholars Fostering Fund of the First Affiliated Hospital of Nanjing Medical University[32000982] ; Young Scholars Fostering Fund of the First Affiliated Hospital of Nanjing Medical University[52403206] ; National Natural Science Foundation of China[505541] ; Doctoral Scientific Research Foundation of Xinxiang Medical University[XDB0830300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[202106270027] ; China Scholarship Council (CSC) |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001544522200001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321219]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Ding, Qihang; Tang, Qiyun; Ma, Gongcheng; Cheng, Zhen |
| 作者单位 | 1.Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr Gastroenterol, Nanjing 210036, Peoples R China 2.Nanjing Med Univ, Nanjing 211166, Peoples R China 3.Xinxiang Med Univ, Nanobiomed Mat Res Ctr, Sch Life Sci & Technol, Xinxiang Key Lab Biomed Mat, Xinxiang 453003, Peoples R China 4.HAUST, Dept Int Cooperat & Exchanges, Luoyang 471023, Henan, Peoples R China 5.Nanjing Med Univ, Affiliated Hosp 1, Dept Neuroendocrine Tumor, Nanjing 210036, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 7.Korea Univ, Dept Chem, Seoul 02841, South Korea |
| 推荐引用方式 GB/T 7714 | Xu, Ruitong,Sun, Kangjun,Li, Yaoqiang,et al. A Viscosity-Responsive Mitochondria-Targeting Ir(III) Probe for Inducing and Monitoring Photodynamic-Triggered Ferroptosis[J]. JOURNAL OF MEDICINAL CHEMISTRY,2025,68(16):17667-17677. |
| APA | Xu, Ruitong.,Sun, Kangjun.,Li, Yaoqiang.,Zhang, Nan.,Liu, Bi.,...&Cheng, Zhen.(2025).A Viscosity-Responsive Mitochondria-Targeting Ir(III) Probe for Inducing and Monitoring Photodynamic-Triggered Ferroptosis.JOURNAL OF MEDICINAL CHEMISTRY,68(16),17667-17677. |
| MLA | Xu, Ruitong,et al."A Viscosity-Responsive Mitochondria-Targeting Ir(III) Probe for Inducing and Monitoring Photodynamic-Triggered Ferroptosis".JOURNAL OF MEDICINAL CHEMISTRY 68.16(2025):17667-17677. |
入库方式： OAI收割
来源：上海药物研究所
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