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Enhancing inter-system crossing efficiency of NIR-II emitting type-I photosensitizers for tumor ferroptosis induction

文献类型：期刊论文

作者Liu, Fen7; Ding, Qihang2; Jia, Jia3; Kang, Qiang4,5; Guo, Jinlin7; Liu, Yu3; Jiang, Ting3; Li, Chao3; Xiang, Jingjing3; Yang, Xing3
刊名ACTA BIOMATERIALIA
出版日期2025-08-01
卷号202页码:476-488
关键词Ferroptosis Type I photosensitizers Photodynamic therapy Reactive oxygen species NIR-II imaging
ISSN号1742-7061
DOI10.1016/j.actbio.2025.07.012
英文摘要Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation (LPO), represents a compelling avenue for cancer therapy. Photodynamic therapy (PDT), which relies on the production of LPOreactive oxygen species (ROS), has emerged as a potent therapeutic strategy. However, the clinical efficacy of conventional photosensitizers (PSs) is frequently constrained by tumor hypoxia, which intensifies local oxygen deficiency and diminishes PDT performance. In contrast, Type I PDT facilitates the generation of cytotoxic ROS, such as superoxide (O-2(-center dot)) through electron transfer mechanisms, offering enhanced oxygen independence and improved therapeutic efficacy. In this study, we introduce a near-infrared (NIR)- activated Type I PS, TPP-TPA, designed via a receptor-engineering strategy. TPP-TPA exhibits robust NIR absorption and NIR-II fluorescence emission, enabling efficient Type I ROS production that induces ferroptosis in 4T1 breast cancer cells. This work establishes a promising approach for cancer therapy and imaging, addressing key limitations of traditional PDT while offering significant potential for clinical translation. Statement of significance: This study presents a near-infrared (NIR)-activated Type I photosensitizer (PS), TPPTPA, designed via a receptor-engineering strategy to overcome the limitations of conventional photodynamic therapy (PDT). By efficiently generating Type I reactive oxygen species (ROS) under NIR activation, TPP-TPA NPs induce ferroptosis in breast cancer cells, offering enhanced oxygen independence and improved therapeutic efficacy. This work advances cancer therapy and imaging by addressing the challenges of tumor hypoxia in PDT, highlighting its potential for clinical translation.
资助项目National Key Research and Development Program of China[2021YFA0910000] ; National Key Research and Development Program of China[2023YFA0915400] ; National Natural Science Foundation of China[22474152] ; Guangdong Provincial Natural Science Foundation[2414050002188] ; Shenzhen Science and Tech-nology Program[JCYJ20210324115804013] ; Shenzhen Science and Tech-nology Program[JCYJ202208181016070 16] ; China Postdoctoral Science Foundation[2023M743687] ; Guangdong Basic and Applied Basic Research Fund Project[2023A1515110611] ; China Scholarship Council[202106270027] ; Gansu Science and Technology Major Project[23ZDFA014] ; State Key Laboratory of Drug Research[SIMM0120231004] ; Shandong Laboratory Program[SYS202205] ; Strategic Priority Research Pro-gram of the Chinese Academy of Sciences[XDB0830300] ; Natural Science Foundation of Hunan Province of China[2025JJ81013] ; Scientific Research Fund of Hunan Province Education Department[24B0393]
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:001544951900024
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/321231]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Ding, Qihang; Xiang, Chunbai; Gong, Ping; Yang, Qinglai; Cheng, Zhen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Korea Univ, Dept Chem, Seoul 02841, South Korea
3.Chinese Acad Sci, Shenzhen Engn Lab Nanomed & Nanoformulat, CAS Key Lab Hlth Informat,Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol,Guangdong Key Lab Nanome, Shenzhen 518055, Peoples R China
4.Univ South China, Canc Res Inst, Ctr Mol Imaging Probe, Sch Pharmaceut Sci,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China
5.Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China
6.Sichuan Univ, Key Lab Green Chem & Technol, Minist Educ, Coll Chem, Chengdu 610064, Peoples R China
7.Univ South China, Affiliated Hosp 2, Dept Radiol, Hengyang 421001, Hunan, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Fen,Ding, Qihang,Jia, Jia,et al. Enhancing inter-system crossing efficiency of NIR-II emitting type-I photosensitizers for tumor ferroptosis induction[J]. ACTA BIOMATERIALIA,2025,202:476-488.
APA Liu, Fen.,Ding, Qihang.,Jia, Jia.,Kang, Qiang.,Guo, Jinlin.,...&Cheng, Zhen.(2025).Enhancing inter-system crossing efficiency of NIR-II emitting type-I photosensitizers for tumor ferroptosis induction.ACTA BIOMATERIALIA,202,476-488.
MLA Liu, Fen,et al."Enhancing inter-system crossing efficiency of NIR-II emitting type-I photosensitizers for tumor ferroptosis induction".ACTA BIOMATERIALIA 202(2025):476-488.

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来源：上海药物研究所

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