Nanotechnology-based shikonin delivery strategies for modulating the tumor immune microenvironment efficacy
文献类型：期刊论文
| 作者 | Kalambhe, Dipika Ramdas6,7; Asrorov, Akmal M.1,8,9; Mukhammedov, Nurkhodja2,3; Huang, Yongzhuo6,7; Wu, Aihua4; Zhao, Pengfei5 |
| 刊名 | DRUG DELIVERY AND TRANSLATIONAL RESEARCH
 |
| 出版日期 | 2025-08-11 |
| 页码 | 16 |
| 关键词 | Nano delivery systems Shikonin PKM2 inhibition Tumor immune microenvironment |
| ISSN号 | 2190-393X |
| DOI | 10.1007/s13346-025-01943-4 |
| 英文摘要 | Malignant tumors remain a major cause of global mortality and pose a formidable threat to human health. While natural and synthetic substances have been explored for cancer therapy, natural products such as shikonin (SHK), a naphthalene quinone extracted from Lithospermum erythrorhizon, offer unique advantages due to their plant-based origins and multifaceted pharmaceutical properties. SHK exhibits potent anticancer activity and inhibits pyruvate kinase M2 (PKM2), which suppresses glycolysis and lactate metabolism. The metabolic regulation inhibits adenosine triphosphate (ATP) production and suppresses the immunosuppressive phenotype of immune cells (e.g., Tregs), thus remodeling the tumor immune microenvironment. Additionally, SHK promotes apoptosis and anti-angiogenesis by affecting key molecular pathways, such as HIF-1 alpha, STAT3, and VEGF. However, its clinical translation is hindered by low water solubility and bioavailability, non-specific toxicity, and rapid systemic clearance. Recent advances in nanotechnology have addressed these limitations through the development of nanosized drug delivery systems, including liposomes, nanoparticles, micelles, nanogels, and other nano-formulations. These systems enhance tumor-targeted delivery, improve pharmacokinetics, and potentiate the immunomodulatory effects of SHK by reprogramming the tumor microenvironment. This review highlights the mechanisms underlying SHK antitumor immunity, evaluates the latest nanotechnology strategies to optimize SHK delivery, and discusses the challenges and prospects for translating SHK-based therapies into clinical practice. |
| WOS关键词 | REGULATORY T-CELLS ; PYRUVATE-KINASE ; LACTIC-ACID ; CANCER-CELLS ; ACTIVATION ; NANOPARTICLES ; THERAPY ; NANOMEDICINES ; DEGRADATION ; METASTASIS |
| 资助项目 | Key Technologies Research and Development Program |
| WOS研究方向 | Instruments & Instrumentation ; Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001548095200001 |
| 出版者 | SPRINGER HEIDELBERG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321261]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Wu, Aihua; Zhao, Pengfei |
| 作者单位 | 1.Ctr Genom & Bioinformat, 2 Univ St, Qibray 111215, Tashkent Region, Uzbekistan 2.Natl Univ Uzbekistan, Dept Nat Cpds & Appl Chem, Tashkent 100174, Uzbekistan 3.Kokand Univ, Andijan Branch, Jasorat 43, Andijan 170619, Uzbekistan 4.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Pharm, 3rd East Qingchun Rd, Hangzhou 310016, Zhejiang, Peoples R China 5.Zhejiang Univ, Ctr Clin Pharmacol, Affiliated Hosp 2, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 8.Uzbek Acad Sci, Inst Bioorgan Chem, 83 M Ulugbek Str, Tashkent 100125, Uzbekistan 9.Alfraganus Univ, 2a Yukori Karakamish St, Tashkent 100190, Uzbekistan |
| 推荐引用方式 GB/T 7714 | Kalambhe, Dipika Ramdas,Asrorov, Akmal M.,Mukhammedov, Nurkhodja,et al. Nanotechnology-based shikonin delivery strategies for modulating the tumor immune microenvironment efficacy[J]. DRUG DELIVERY AND TRANSLATIONAL RESEARCH,2025:16. |
| APA | Kalambhe, Dipika Ramdas,Asrorov, Akmal M.,Mukhammedov, Nurkhodja,Huang, Yongzhuo,Wu, Aihua,&Zhao, Pengfei.(2025).Nanotechnology-based shikonin delivery strategies for modulating the tumor immune microenvironment efficacy.DRUG DELIVERY AND TRANSLATIONAL RESEARCH,16. |
| MLA | Kalambhe, Dipika Ramdas,et al."Nanotechnology-based shikonin delivery strategies for modulating the tumor immune microenvironment efficacy".DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2025):16. |
入库方式： OAI收割
来源：上海药物研究所
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