Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy
文献类型：期刊论文
| 作者 | Happonen, Emilia2; Dang, Yijing3; Wang, Jiajia2; Saarela, Silja2; Sivonen, Minna2; Zakir, Mohammed2; Laari, Milla-Iida2; Constantinou, Yiannis2; Tamarov, Konstantin2; Hakkarainen, Henri4 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2025-08-20 |
| 卷号 | 17期号:33页码:46521-46534 |
| 关键词 | antitumor immune response drug-free photothermaltherapy porous silicon nanoparticles tumor immunemicroenvironment |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.5c05042 |
| 英文摘要 | A proto-oncogene MYC plays a crucial role in controlling immune response, but as of today, it is undruggable. Some MYC inhibitors are under testing; nevertheless, they have low efficacy and severe toxicity. Up to now, the use of a drug-free approach to regulate MYC has been rarely investigated. The present study aims to identify the potential of drug-free photothermal therapy (PTT) in regulating MYC. Herein, biomimetic black porous silicon (BPSi) nanoparticles (NPs) were prepared via a novel self-templated Na-K alloy reduction method and then coated with a cancer cell membrane and polyethylene glycol. These NPs have efficient photothermal conversion, good biocompatibility, and homotypic tumor targeting. The results indicated that BPSi-based PTT could efficiently regulate MYC by tuning temperatures. However, only PTT at 50 degrees C could successfully inhibit MYC, while PTT at 46 degrees C upregulated MYC. Mechanism studies revealed that MYC inhibition was achieved via the downregulation of 'MYC Targets V1', and MAPK and JAK-STAT signaling pathways were involved. Finally, tumor-targeted PTT activated robust cancer immunotherapy by MYC inhibition and efficiently prevented tumor growth without significant toxicity in vivo. The present study highlights the potential of a drug-free approach to regulate MYC for more potent cancer immunotherapy. |
| WOS关键词 | APOPTOTIC CELLS ; SILICON ; AGENT ; QUANTIFICATION ; SIGNAL |
| 资助项目 | National Natural Science Foundation of China ; Finnish Cultural Foundation ; Research Council of Finland[356056] ; Research Council of Finland[359706] ; Research Council of Finland[352968] ; Research Council of Finland[356992] ; Academy of Finland[32311530041] ; National Natural Science Foundation of China ; Biocenter Finland |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001548282500001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321273]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Xu, Zhiai; Xu, Wujun |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 20120, Peoples R China 2.Univ Eastern Finland, Dept Tech Phys, Kuopio, Finland 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 4.Univ Eastern Finland, Dept Environm & Biol Sci, Kuopio 70210, Finland 5.Univ Eastern Finland, Sch Pharm, PromisLab, Kuopio, Finland 6.Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland 7.Univ Helsinki, Med Fac, Canc Cell Circuitry Lab, Translat Canc Med, FI-00014 Helsinki, Finland 8.Finnish Canc Inst, , Finlandd, Helsinki, Finland 9.South Helsinki Univ Hosp, FICAN South, Helsinki 00290, Finland 10.Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA |
| 推荐引用方式 GB/T 7714 | Happonen, Emilia,Dang, Yijing,Wang, Jiajia,et al. Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy[J]. ACS APPLIED MATERIALS & INTERFACES,2025,17(33):46521-46534. |
| APA | Happonen, Emilia.,Dang, Yijing.,Wang, Jiajia.,Saarela, Silja.,Sivonen, Minna.,...&Xu, Wujun.(2025).Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy.ACS APPLIED MATERIALS & INTERFACES,17(33),46521-46534. |
| MLA | Happonen, Emilia,et al."Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy".ACS APPLIED MATERIALS & INTERFACES 17.33(2025):46521-46534. |
入库方式： OAI收割
来源：上海药物研究所
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