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Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer

文献类型：期刊论文

作者Yi, Wen-zhe1,7,8; Qian, Xin-di2,3,7,8; Xu, Xiao-xuan1,7,8; Pu, Rong4; Yan, Dan7,8; Zhao, Zhi-wen1,7,8; Li, Ya-ping1,4,6,7,8; Wang, Dang-ge5
刊名ACTA PHARMACOLOGICA SINICA
出版日期2025-08-08
页码12
关键词dendritic cell liposome colitis-associated cancer marrow-derived immunosuppressive cell tumor-associated macrophage
ISSN号1671-4083
DOI10.1038/s41401-025-01614-7
英文摘要The progression of colitis-associated cancer (CAC) is strongly associated with bone marrow-derived immunosuppressive cells (MDSCs). Although CAC could be suppressed by inducing MDSCs apoptosis, the immunosuppressive tumor microenvironment (TME) maintains immune homeostasis by upregulating M2-type tumor-associated macrophages (TAMs), thus leading to adaptive immune tolerance. Herein, we develop a dendritic cell (DC)-liposome conjugate to reverse immunosuppressive TME, showing remarkable efficiency against colorectal cancer. The DC-liposome conjugate is fabricated by conjugating resolvin E1-loaded liposomes with Fas ligand-transfected DCs, which eliminates tumor-infiltrated Fas+ MDSCs and enhances TAM phagocytosis in tumors. It shows significant therapeutic effects in preclinical CAC models and alleviates severe colitis when combined with immune checkpoint inhibitors. This study provides a feasible and customized cell-drug conjugate to overcome immunosuppressive TME for enhancing CAC immunotherapy.
WOS关键词RESOLVIN E1 ; MECHANISMS ; RECEPTOR ; ACTIVATION
资助项目National Key R&D Program of China[2022YFC3401404] ; National Natural Science Foundation of China[32170935] ; Strategic Priority Research Program of the Chinese Academy of Grant[XDC0290302] ; Science and Technology Commission of Shanghai Municipality[24J22800600] ; Shandong Laboratory Program[SYS202205]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001546027900001
出版者NATURE PUBL GROUP
源URL[http://119.78.100.183/handle/2S10ELR8/321288]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Li, Ya-ping; Wang, Dang-ge
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Med Ultrasound,Ultrasound Res & Educ Inst, Shanghai 200072, Peoples R China
3.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Ultrasound Res & Educ Inst,Ctr Minimally Invas Tre, Shanghai 200072, Peoples R China
4.Nanjing Univ Chinese Med, Nanjing 210023, Peoples R China
5.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Sch Med, Shanghai 201620, Peoples R China
6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yi, Wen-zhe,Qian, Xin-di,Xu, Xiao-xuan,et al. Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer[J]. ACTA PHARMACOLOGICA SINICA,2025:12.
APA Yi, Wen-zhe.,Qian, Xin-di.,Xu, Xiao-xuan.,Pu, Rong.,Yan, Dan.,...&Wang, Dang-ge.(2025).Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer.ACTA PHARMACOLOGICA SINICA,12.
MLA Yi, Wen-zhe,et al."Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer".ACTA PHARMACOLOGICA SINICA (2025):12.

入库方式： OAI收割

来源：上海药物研究所

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