Mitochondrial Metabolomics in Cancer: Mass Spectrometry-Based Approaches for Metabolic Rewiring Analysis and Therapeutic Discovery
文献类型：期刊论文
| 作者 | Gao, Yuqing2,3,4; Xiong, Zhirou1,5; Wei, Xinyi6 |
| 刊名 | METABOLITES
 |
| 出版日期 | 2025-07-31 |
| 卷号 | 15期号:8页码:38 |
| 关键词 | mitochondrial metabolomics mass spectrometry mitochondria isolation targeted metabolomics untargeted metabolomics |
| DOI | 10.3390/metabo15080513 |
| 英文摘要 | Mitochondria, pivotal organelles in cellular metabolism and energy production, have emerged as critical players in the pathogenesis of cancer. This review outlines the progress in mitochondrial profiling through mass spectrometry-based metabolomics and its applications in cancer research. We provide unprecedented insights into the mitochondrial metabolic rewiring that fuels tumorigenesis, metastasis, and therapeutic resistance. The purpose of this review is to provide a comprehensive guide for the implementation of mitochondrial metabolomics, integrating advanced methodologies-including isolation, detection, and data integration-with insights into cancer-specific metabolic rewiring. We first summarize current methodologies for mitochondrial sample collection and pretreatment. Furthermore, we then discuss the recent advancements in mass spectrometry-based methodologies that facilitate the detailed profiling of mitochondrial metabolites, unveiling significant metabolic reprogramming associated with tumorigenesis. We emphasize how recent technological advancements have addressed longstanding challenges in the field and explore the role of mitochondrial metabolism-driven cancer development and progression for novel drug discovery and translational research applications in cancer. Collectively, this review delineates emerging opportunities for therapeutic discovery and aims to establish a foundation for future investigations into the therapeutic modulation of mitochondrial pathways in cancer, thereby paving the way for innovative diagnostic and therapeutic approaches targeting mitochondrial pathways. |
| WOS关键词 | QUALITY-CONTROL MECHANISMS ; ACUTE MYELOID-LEUKEMIA ; RENAL-CELL CARCINOMA ; FATTY-ACID SYNTHESIS ; POOR-PROGNOSIS ; GLUTAMINE-METABOLISM ; WHOLE ANIMALS ; ASPARAGINE ; MUTATIONS ; GERMLINE |
| 资助项目 | Startup Fund for Advanced Talents of Putian University ; [2024132] ; [2024169] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001557993700001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321339]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Wei, Xinyi |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Putian Univ, Sch Pharm & Med Technol, Putian 351100, Peoples R China 3.Putian Univ, Fujian Prov Univ, Key Lab Pharmaceut Anal & Lab Med, Putian 351100, Peoples R China 4.Putian Univ, Fujian Prov Univ, Key Lab Med Microecol, Putian 351100, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 100864, Peoples R China 6.Putian Univ, Sch Nursing, Putian 351100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yuqing,Xiong, Zhirou,Wei, Xinyi. Mitochondrial Metabolomics in Cancer: Mass Spectrometry-Based Approaches for Metabolic Rewiring Analysis and Therapeutic Discovery[J]. METABOLITES,2025,15(8):38. |
| APA | Gao, Yuqing,Xiong, Zhirou,&Wei, Xinyi.(2025).Mitochondrial Metabolomics in Cancer: Mass Spectrometry-Based Approaches for Metabolic Rewiring Analysis and Therapeutic Discovery.METABOLITES,15(8),38. |
| MLA | Gao, Yuqing,et al."Mitochondrial Metabolomics in Cancer: Mass Spectrometry-Based Approaches for Metabolic Rewiring Analysis and Therapeutic Discovery".METABOLITES 15.8(2025):38. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。