Viroporins: emerging viral infection mechanisms and therapeutic targets
文献类型：期刊论文
| 作者 | Qu, Yuxin1; Li, Jiaqi1; Deng, Hao1; Wang, Yanjin1; Li, Lian-Feng1; Xia, Bingqing2; Li, Yongfeng1; Qiu, Hua-Ji1; Li, Su1 |
| 刊名 | JOURNAL OF VIROLOGY
 |
| 出版日期 | 2025-09-02 |
| 页码 | 16 |
| 关键词 | viroporins virus life cycle ion homeostasis proinflammatory responses antiviral strategies |
| ISSN号 | 0022-538X |
| DOI | 10.1128/jvi.01038-25 |
| 英文摘要 | Viroporins, virus-encoded small hydrophobic proteins, are involved in critical steps of viral infections by modulating ion homeostasis, disrupting host membrane integrity, and orchestrating key stages of the virus life cycle-from entry and replication to release. Beyond facilitating viral propagation, these pore-forming proteins exacerbate pathogenesis by disrupting cellular ion homeostasis and triggering proinflammatory responses through NLRP3 inflammasome activation. Their dual role in viral fitness and immunopathology positions viroporins as promising antiviral targets for dual-action therapeutics: suppressing replication while attenuating inflammation. However, structural constraints and low immunogenicity hinder vaccine development targeting conserved viroporin domains. This review summarizes recent advances in viroporin mechanisms, highlights progress in viroporin-targeted drug and vaccine design, and discusses persistent challenges. Furthermore, the emerging technologies (e.g., AI-driven structural prediction and nanodelivery systems) are expected to significantly accelerate the development of next-generation viroporin-targeted therapeutics and vaccines. Taken together, this review underscores the critical roles of viroporins in viral pathogenesis, emphasizing their potential as promising targets for the prevention and control of viral diseases. |
| WOS关键词 | VIRUS-LIKE PARTICLE ; INFLUENZA-VIRUS ; M2 PROTEIN ; ENDOPLASMIC-RETICULUM ; CHANNEL ; VACCINE ; INFLAMMATION ; COMBINATION ; MUTATIONS ; CALCIUM |
| 资助项目 | National Natural Science Foundation of China[32473002] ; National Natural Science Foundation of China[TD2023C007] ; Heilongjiang Provincial Natural Science Foundation of China |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:001561736200001 |
| 出版者 | AMER SOC MICROBIOLOGY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321354]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Qiu, Hua-Ji; Li, Su |
| 作者单位 | 1.Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Harbin, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qu, Yuxin,Li, Jiaqi,Deng, Hao,et al. Viroporins: emerging viral infection mechanisms and therapeutic targets[J]. JOURNAL OF VIROLOGY,2025:16. |
| APA | Qu, Yuxin.,Li, Jiaqi.,Deng, Hao.,Wang, Yanjin.,Li, Lian-Feng.,...&Li, Su.(2025).Viroporins: emerging viral infection mechanisms and therapeutic targets.JOURNAL OF VIROLOGY,16. |
| MLA | Qu, Yuxin,et al."Viroporins: emerging viral infection mechanisms and therapeutic targets".JOURNAL OF VIROLOGY (2025):16. |
入库方式： OAI收割
来源：上海药物研究所
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