Advances in therapeutic strategies for acute kidney injury
文献类型：期刊论文
| 作者 | Song, Shuangyan1; Su, Wuyue2,3,6; Wang, Hongbo1; Hong, Xuechuan2,3,4,5; Xiao, Yuling2,3,6; Zeng, Xiaodong2 |
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2025-11-01 |
| 卷号 | 380页码:16 |
| 关键词 | Acute kidney injury Nephrotoxicity Sepsis Ischemia-reperfusion injury Therapeutic strategy |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/j.lfs.2025.123943 |
| 英文摘要 | Acute Kidney Injury (AKI) is a complex clinical syndrome marked by a rapid decline in renal function, most commonly triggered by ischemia, hypoxia, or nephrotoxic insults, and is associated with significant morbidity and mortality. Despite advances in understanding its underlying mechanisms, current treatments remain predominantly supportive, with no effective therapies available to reverse or repair renal damage. Although biomarker-guided precision medicine holds promise, its clinical utility requires further validation through largescale trials. This review summarizes recent progress in AKI therapy, with a particular focus on injury induced by nephrotoxic drugs (cisplatin, aminoglycosides, contrast media), sepsis, and ischemia-reperfusion. It discusses innovative strategies including nanomedicine-based drug delivery, plant-derived therapeutics, ferroptosis inhibition, and gene or microRNA-targeted approaches, alongside emerging clinical interventions and assessment tools. By bridging experimental findings with clinical application, this review provides insight into evolving therapeutic avenues and emphasizes the ongoing need for targeted, effective interventions to improve outcomes in AKI. |
| WOS关键词 | MITOCHONDRIAL DYSFUNCTION ; CONTRAST-MEDIA ; SEPSIS ; NEPHROTOXICITY ; NANOPARTICLES ; PROTECTION ; AUTOPHAGY ; OUTCOMES ; MODEL |
| 资助项目 | NSFC Key International (Regional) Joint Research Program[W2511012] ; National Key Research and Development Program of China[2023YFC3605500] ; National Natural Science Foundation of China[22477129] ; National Natural Science Foundation of China[82273796] ; Taishan Scholar Project of Shandong Province[TSQN202306320] ; Natural Science Foundation of Shandong Province[ZR2023MB085] ; Natural Science Foundation of Shandong Province[ZR2024QH253] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515012649] ; Tibet Autonomous Region Science and Technology Plan Project Key Project[XZ202301ZY0014G] ; The 2024 Science and Technology Planning Project of Lhasa[LSKJ202445] ; Shandong Laboratory Program[SYS202205] ; Special Supporting Funds for Leading Talents at or above the Provincial Level in Yantai |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001566921200001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321411]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Hong, Xuechuan; Xiao, Yuling; Zeng, Xiaodong |
| 作者单位 | 1.Yantai Univ, Biotech Drugs Univ Shandong, Collaborat Innovat Ctr Adv Drug Delivery Syst, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat,Min, Yantai 264005, Shandong, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Radiol, Wuhan 430071, Peoples R China 5.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 6.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Shuangyan,Su, Wuyue,Wang, Hongbo,et al. Advances in therapeutic strategies for acute kidney injury[J]. LIFE SCIENCES,2025,380:16. |
| APA | Song, Shuangyan,Su, Wuyue,Wang, Hongbo,Hong, Xuechuan,Xiao, Yuling,&Zeng, Xiaodong.(2025).Advances in therapeutic strategies for acute kidney injury.LIFE SCIENCES,380,16. |
| MLA | Song, Shuangyan,et al."Advances in therapeutic strategies for acute kidney injury".LIFE SCIENCES 380(2025):16. |
入库方式： OAI收割
来源：上海药物研究所
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