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PLGA nanomedicine for inflammatory bowel disease: targeted delivery and integrated diagnostics toward precision treatment

文献类型：期刊论文

作者Ding, Qihang1,2; Luo, Yi1; Wu, Hao3; Tao, Jing1; Zhang, Yibin1; Yin, Gang1; Qian, Kun4; Chen, Yungchang5; Mei, Ling1; Cheng, Zhen4
刊名SCIENCE CHINA-CHEMISTRY
出版日期2025-09-02
页码32
关键词inflammatory bowel disease PLGA nanomedicine diagnosis drug delivery
ISSN号1674-7291
DOI10.1007/s11426-025-2889-2
英文摘要Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract with increasing global prevalence. Conventional therapeutic strategies are limited by suboptimal efficacy, systemic side effects, and poor patient compliance, while current diagnostic approaches lack sufficient sensitivity and specificity. The advent of nanotechnology, particularly poly(lactic-co-glycolic acid) (PLGA)-based nanomedicine, offers promising avenues for both the diagnosis and treatment of IBD. PLGA nanomedicine exhibits excellent biocompatibility, biodegradability, and controlled drug release properties, enabling targeted and efficient therapeutic delivery. This review comprehensively summarizes recent advances in PLGA-based nanocarriers for IBD management, focusing on innovative design strategies including core-shell architectures, multi-targeting approaches, immune modulation, stimuli-responsive systems, and combination therapies. We also discuss mechanisms to overcome gastrointestinal barriers, enhance mucosal penetration, and modulate the gut immune microenvironment. Furthermore, the integration of diagnostic imaging with therapeutic modalities improves precision in IBD diagnosis. Despite challenges related to long-term safety, large-scale manufacturing, and clinical translation, PLGA nanomedicine holds significant potential for personalized, multidisciplinary IBD treatment, positioning itself as a transformative solution in the field.
WOS关键词PH-SENSITIVE NANOPARTICLES ; ALLEVIATE ULCERATIVE-COLITIS ; TNF-ALPHA SIRNA ; OF-THE-ART ; DRUG-DELIVERY ; ORAL DELIVERY ; POLYMERIC NANOPARTICLES ; POLYETHYLENE-GLYCOL ; COLONIC DELIVERY ; POLYLACTIC ACID
资助项目China Scholarship Council (CSC)[202106270027] ; National Natural Science Foundation of China[U2267221] ; Shandong Laboratory Program[SYS202205] ; State Key Laboratory of Drug Research[SIMM0120231004] ; Gansu Science and Technology Major Project[23ZDFA014] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB0830300] ; Open Subject Funding of Sichuan Engineering and Technology Research Center for Industrialization of Antiviral Chinese Medicines of Sichuan Guangda Pharmaceutical Co., Ltd[KT2024-002] ; Open Subject Funding of Sichuan Engineering and Technology Research Center for Industrialization of Antiviral Chinese Medicines of Sichuan Guangda Pharmaceutical Co., Ltd[KT2024-003] ; Chinese Southwest Oncology Group[CSWOG202101004] ; Chinese Southwest Oncology Group[CSWOG202101002] ; Health Commission of Sichuan Province, Science and Technology Project[23LCYJ025] ; Jiangsu Xiansheng Zaiming Pharmaceutical Co., Ltd. ; Chengdu University[2081920011] ; Chengdu University[2024JA008]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001566246300001
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/321426]  
专题国家级研究中心_原创新药研究全国重点实验室
通讯作者Ding, Qihang; Mei, Ling; Cheng, Zhen; Shen, Xue
作者单位1.Chengdu Univ, Sichuan Ind Inst Antibiot, Engn Res Ctr Pharmaceut & Equipments Sichuan Prov, Sch Pharm, Chengdu 610106, Peoples R China
2.Korea Univ, Dept Chem, Seoul 02841, South Korea
3.Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610072, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Dept Med Oncol,Sch Med, Chengdu 610041, Peoples R China
推荐引用方式
GB/T 7714		 Ding, Qihang,Luo, Yi,Wu, Hao,et al. PLGA nanomedicine for inflammatory bowel disease: targeted delivery and integrated diagnostics toward precision treatment[J]. SCIENCE CHINA-CHEMISTRY,2025:32.
APA Ding, Qihang.,Luo, Yi.,Wu, Hao.,Tao, Jing.,Zhang, Yibin.,...&Shen, Xue.(2025).PLGA nanomedicine for inflammatory bowel disease: targeted delivery and integrated diagnostics toward precision treatment.SCIENCE CHINA-CHEMISTRY,32.
MLA Ding, Qihang,et al."PLGA nanomedicine for inflammatory bowel disease: targeted delivery and integrated diagnostics toward precision treatment".SCIENCE CHINA-CHEMISTRY (2025):32.

入库方式： OAI收割

来源：上海药物研究所

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