Advances in near-infrared fluorescence imaging for early detection of acute kidney injury
文献类型：期刊论文
| 作者 | Bai, Wenjing; Su, Wuyue1,2,3; Zhang, Peng; Hong, Xuechuan2,3,4,5,6,7; Xiao, Yuling1,2,3; Zeng, Xiaodong2,3 |
| 刊名 | DYES AND PIGMENTS
 |
| 出版日期 | 2026-02-01 |
| 卷号 | 245页码:15 |
| 关键词 | Acute kidney injury Near-infrared Biomarkers Fluorescence probes Early diagnosis |
| ISSN号 | 0143-7208 |
| DOI | 10.1016/j.dyepig.2025.113231 |
| 英文摘要 | Acute kidney injury (AKI) is a severe clinical condition with complex pathogenesis and high morbidity. Early diagnosis is vital for improving outcomes, but traditional markers such as serum creatinine and urine output lack sensitivity and timeliness. Near-infrared (NIR) fluorescence imaging has emerged as a promising tool for early AKI detection due to its deep tissue penetration, high sensitivity, and real-time monitoring capability. This review summarizes the design strategies of NIR fluorescent probes, including fluorophore optimization, linker engineering, and targeting group selection. We focus on their applications in detecting AKI biomarkers, such as Vanin-1, KIM-1, and LAP, which enable sensitive detection in urine or kidney tissue through enzymatic or receptor-mediated mechanisms. Probes targeting oxidative stress markers like reactive oxygen species and peroxynitrite further allow dynamic visualization of early AKI-related changes. Despite their advantages, clinical translation of NIR probes faces challenges, including biocompatibility, targeting precision, imaging depth, and integration with multimodal platforms. Continued optimization of probe design is essential to advance their use in early AKI diagnosis and precision medicine. |
| WOS关键词 | GELATINASE-ASSOCIATED LIPOCALIN ; MOLECULE-1 KIM-1 ; II FLUORESCENCE ; CYSTATIN-C ; BIOMARKER ; PROBE ; PHOTOSTABILITY ; IDENTIFICATION ; MECHANISMS ; FAILURE |
| 资助项目 | NSFC Key International (Regional) Joint Research Program[W2511012] ; National Key R & D Program of China[2023YFC3605500] ; National Natural Science Foundation of China[22477129] ; National Natural Science Foundation of China[82273796] ; Taishan Scholar Project of Shandong Province[TSQN202306320] ; Special Supporting Funds for Leading Talents at or above the Provincial Level in Yantai ; Natural Science Foundation of Shandong Province[ZR2023MB085] ; Natural Science Foundation of Shandong Province[ZR2024QH253] ; Shandong Laboratory Program[SYS202205] ; Shenzhen Science and Technology Research[JCYJ20240813111300001] ; Shenzhen Science and Technology Research[JCYJ20220530140605012] ; Shenzhen Science and Technology Research[JCYJ20230807090100002] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515012649] ; Tibet Autonomous Region Science and Technology Plan Project Key Project[XZ202301ZY0014G] ; The 2024 Science and Technology Planning Project of Lhasa[LSKJ202445] |
| WOS研究方向 | Chemistry ; Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001573033900001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321483]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Hong, Xuechuan; Xiao, Yuling; Zeng, Xiaodong |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 6.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Radiol, Wuhan 430071, Peoples R China 7.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Wenjing,Su, Wuyue,Zhang, Peng,et al. Advances in near-infrared fluorescence imaging for early detection of acute kidney injury[J]. DYES AND PIGMENTS,2026,245:15. |
| APA | Bai, Wenjing,Su, Wuyue,Zhang, Peng,Hong, Xuechuan,Xiao, Yuling,&Zeng, Xiaodong.(2026).Advances in near-infrared fluorescence imaging for early detection of acute kidney injury.DYES AND PIGMENTS,245,15. |
| MLA | Bai, Wenjing,et al."Advances in near-infrared fluorescence imaging for early detection of acute kidney injury".DYES AND PIGMENTS 245(2026):15. |
入库方式： OAI收割
来源：上海药物研究所
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