Three New Diterpenoids From Phyllanthus emblica Roots: Structure and Anti-HIV Activity
文献类型：期刊论文
| 作者 | Jiang, Zi-Jian2,3; Hu, Meng-Yu1; Li, Ling-Hui3; Zhou, Bin3,4; Wang, Qian1; Fan, Yao-Yue3,4; Yue, Jian-Min2,3,4 |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2025-08-01 |
| 卷号 | 22期号:8页码:7 |
| 关键词 | anti-HIV
cleistanthane-type diterpenoid, |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202500783 |
| 英文摘要 | Three undescribed aromatic diterpenoids (1-3), were isolated from the roots of Phyllanthus emblica and structurally characterized. Compounds 1 and 2 are cleistanthane-type diterpenoids, and the latter possesses a rare 4,5-seco-20(10 -> 5)-abeo-ent-cleistanthane scaffold with an acetenyl at C-14. Compound 3 was elucidated as a new podocarpane trinorditerpenoid. The structural elucidation, including absolute configuration determination, was achieved through comprehensive spectroscopic analysis (nuclear magnetic resonance, mass spectrometry, ultraviolet, and infrared) combined with time-dependent density functional theory-based electronic circular dichroism calculations. Compound 2 showed potential activity against HIV-1Bal PsV infection with an IC50 value of 3.30 mu M. |
| WOS关键词 | SESQUITERPENOID GLYCOSIDES ; ABSOLUTE-CONFIGURATIONS ; A-F ; NORBISABOLANE ; EXTRACTS ; FRUIT |
| 资助项目 | National Key Research and Development Program of China[2023YFE0206100] ; National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[22177122] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001489852000001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/321495]  |
| 专题 | 国家级研究中心_原创新药研究全国重点实验室 |
| 通讯作者 | Fan, Yao-Yue; Yue, Jian-Min |
| 作者单位 | 1.Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Shanghai Frontiers Sci Ctr Pathogen Microorganisms, Sch Basic Med Sci,Key Lab Med Mol Virol MOE NHC CA, Shanghai, Peoples R China 2.Nanchang Univ, Jiangxi Med Coll, Sch Pharm, Nanchang, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zi-Jian,Hu, Meng-Yu,Li, Ling-Hui,et al. Three New Diterpenoids From Phyllanthus emblica Roots: Structure and Anti-HIV Activity[J]. CHEMISTRY & BIODIVERSITY,2025,22(8):7. |
| APA | Jiang, Zi-Jian.,Hu, Meng-Yu.,Li, Ling-Hui.,Zhou, Bin.,Wang, Qian.,...&Yue, Jian-Min.(2025).Three New Diterpenoids From Phyllanthus emblica Roots: Structure and Anti-HIV Activity.CHEMISTRY & BIODIVERSITY,22(8),7. |
| MLA | Jiang, Zi-Jian,et al."Three New Diterpenoids From Phyllanthus emblica Roots: Structure and Anti-HIV Activity".CHEMISTRY & BIODIVERSITY 22.8(2025):7. |
入库方式： OAI收割
来源：上海药物研究所
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